系统性红斑狼疮自身抗体研究进展

被引:11
作者
代荣琴 [1 ]
张金彪 [2 ]
刘玉枝 [1 ]
陈洋 [1 ]
机构
[1] 沧州医学高等专科学校检验教研室
[2] 沧州中西医结合医院实验诊断科
关键词
系统性红斑狼疮; 自身抗体;
D O I
暂无
中图分类号
R593.241 [];
学科分类号
摘要
经化学修饰的组织抗原,与正常组织成分有交叉反应的外来抗原、隔绝的体内自身成分及低分化的组织抗原等在一定条件下可刺激机体组织产生自身抗体。某些自身抗体因对系统性红斑狼疮(SLE)的判断具有高度特异性,已成为诊断SLE的血清指标或特异性抗体,有些自身抗体与疾病的活动性有相关性。因此,测定自身抗体有助于SLE的诊断,并对疾病的活动程度,观察治疗效果,指导临床用药具有重要的临床意义。
引用
收藏
相关论文
共 8 条
[1]
钙调神经磷酸酶-活化T细胞核因子与系统性红斑狼疮 [J].
张群燕 ;
蔡辉 .
国际免疫学杂志, 2012, (02)
[2]
年龄、职业和免疫因素与系统性红斑狼疮及狼疮性肾炎的关系 [J].
周海舟 ;
张萱 ;
林春艳 ;
张志毅 ;
关秀茹 .
国际免疫学杂志, 2011, (02)
[3]
Chinese SLE Treatment and Research Group Registry: III. Association of Autoantibodies with Clinical Manifestations in Chinese Patients with Systemic Lupus Erythematosus.[J].Jing Li;Xiaomei Leng;Zhijun Li;Zhizhong Ye;Caifeng Li;Xiaofeng Li;Ping Zhu;Zhengang Wang;Yi Zheng;Xiangpei Li;Miaojia Zhang;Xin-Ping Tian;Mengtao Li;Jiuliang Zhao;Feng-Chun Zhang;Yan Zhao;Xiaofeng Zeng;Marvin J. Fritzler.Journal of Immunology Research.2014,
[4]
Anti-C1q antibodies and systemic lupus erythematosus in the Tunisian population [J].
Trad, B. ;
Ben Hassine, H. ;
Khalifa, M. ;
Idriss, N. ;
Slama, F. ;
Bahri, F. ;
Kechrid, C. Laouani ;
Boukadida, J. ;
Sghiri, R. .
PATHOLOGIE BIOLOGIE, 2013, 61 (03) :113-116
[5]
Up regulation of serum tumor necrosis factor- related apoptosis inducing ligand in juvenile- onset systemic lupus erythematosus: relations with disease activity, antibodies to double - stranded DNA, nephritis and neutropenia [J].
Ezzat, Mohamed H. M. ;
EL-Gammasy, Tarek M. A. ;
Shaheen, Kareem Y. A. ;
EL-Mezdawi, Ramzi A. M. ;
Youssef, Mervat S. M. .
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, 2013, 16 (03) :310-318
[6]
Simultaneous Positivity for Anti-DNA, Anti-Nucleosome and Anti-Histone Antibodies is a Marker for More Severe Lupus Nephritis [J].
Sui, Mansu ;
Lin, Qingyuan ;
Xu, Zhaozhen ;
Han, Xiaojing ;
Xie, Rujuan ;
Jia, Xiuzhi ;
Guo, Xiaofang ;
Zhang, Weihua ;
Guan, Xiuru ;
Ren, Huan .
JOURNAL OF CLINICAL IMMUNOLOGY, 2013, 33 (02) :378-387
[7]
Are anti-nucleosome antibodies a better diagnostic marker than anti-dsDNA antibodies for systemic lupus erythematosus? A systematic review and a study of metanalysis [J].
Bizzaro, Nicola ;
Villalta, Danilo ;
Giavarina, Davide ;
Tozzoli, Renato .
AUTOIMMUNITY REVIEWS, 2012, 12 (02) :97-106
[8]
Anti-C1q antibody is a valuable biological marker for prediction of renal pathological characteristics in lupus nephritis [J].
Chen, Zhu ;
Wang, Guo-Sheng ;
Wang, Gui-Hong ;
Li, Xiang-Pei .
CLINICAL RHEUMATOLOGY, 2012, 31 (09) :1323-1329