石英晶体微天平在蛋白吸附领域的研究进展

被引：15

作者：

李贵才

朱生发

杨苹

黄楠

机构：

[1] 四川成都西南交通大学材料科学与工程学院

来源：

传感器世界 | 2007年 / 12期

关键词：

QCM; 蛋白吸附; 纤维蛋白原; 白蛋白; 免疫球蛋白; 血红蛋白; 低密度脂蛋白;

D O I：

10.16204/j.cnki.sw.2007.12.005

中图分类号：

TP212 [发送器（变换器）、传感器];

学科分类号：

140102 [集成电路设计与设计自动化];

摘要：

石英晶体微天平(Quartz Crystal Microbalance,QCM)是一类重要的质量敏感型传感器,其检测限可以达到10%～9g,具有特异性好、灵敏度高、样品无需标记和操作简便的优点。QCM最初应用于气相反应环境,从20世纪80年代开始逐步用于液相反应环境之中,现在已经广泛应用于环境监测和生物医学等各个领域。QCM用于蛋白吸附领域的研究,可以实时动态地监测蛋白吸附的整个过程,包括吸附蛋白的质量、吸附层的厚度、粘弹性变化信息及吸附蛋白的构象变化等等。本文就QCM的原理、应用和蛋白吸附的研究现状进行了简要介绍,综述了近几年QCM用于蛋白吸附领域的研究现状,并对其发展进行了展望。

引用

页码：6 / 10

页数：5

共 22 条

[1]

The adsorption of globular proteins; bovine serum albumin and β-lactoglobulin; on poly- l -lysine–furcellaran multilayers.[J].K. Laos;R. Parker;J. Moffat;N. Wellner;S.G. Ring.Carbohydrate Polymers.2006, 3

[2]

The effect of silica nanoparticulate coatings on serum protein adsorption and cellular response [J].

Lord, M. S. ;

Cousins, B. G. ;

Doherty, P. J. ;

Whitelock, J. M. ;

Simmons, A. ;

Williams, R. L. ;

Milthorpe, B. K. .

BIOMATERIALS, 2006, 27 (28) :4856-4862

[3]

Hydration–dehydration of adsorbed protein films studied by AFM and QCM-D.[J].G.V. Lubarsky;M.R. Davidson;R.H. Bradley.Biosensors and Bioelectronics.2006, 7

[4]

An adsorption behavior of low-density lipoprotein onto cholesterol-modified dextran studied by a quartz crystal microbalance.[J].Dongbo Liu;Bingjun He;Songyan Han;Shenqi Wang;Qingping Liu;Anzai Jun-ichi;Tetsuo Osa;Qiang Chen.Materials Science & Engineering C.2006, 4

[5]

Adsorption of fluorescently labeled protein residues on poly(ethylene-co-acrylic acid) films modified with affinity functionalities [J].

Luo, Ning ;

Zhang, Chun ;

Hirt, Douglas E. ;

Husson, Scott M. .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2006, 50 (02) :89-96

[6]

Determination of albumin concentration by MIP-QCM sensor [J].

Lin, TY ;

Hu, CH ;

Chou, TC .

BIOSENSORS & BIOELECTRONICS, 2004, 20 (01) :75-81

[7]

Highly dense protein layers confirmed by atomic force microscopy and quartz crystal microbalance [J].

Kim, J ;

Yamasaki, R ;

Park, J ;

Jung, H ;

Lee, H ;

Kawai, T .

JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 2004, 97 (02) :138-140

[8]

Quartz crystal biosensor for real-time monitoring of molecular recognition between protein and small molecular medicinal agents [J].

Liu, Y ;

Yu, X ;

Zhao, R ;

Shangguan, DH ;

Bo, ZY ;

Liu, GQ .

BIOSENSORS & BIOELECTRONICS, 2003, 19 (01) :9-19

[9]

Conventional detection method of fibrinogen and fibrin degradation products using latex piezoelectric immunoassay.[J].Hidenobu Aizawa;Shigeru Kurosawa;Mitsuhiro Tozuka;Jong-Won Park;Koichi Kobayashi;Hideo Tanaka.Biosensors and Bioelectronics.2003, 5

[10]

A comparative study of protein adsorption on titanium oxide surfaces using in situ ellipsometry, optical waveguide lightmode spectroscopy, and quartz crystal microbalance/dissipation [J].

Höök, F ;

Vörös, J ;

Rodahl, M ;

Kurrat, R ;

Böni, P ;

Ramsden, JJ ;

Textor, M ;

Spencer, ND ;

Tengvall, P ;

Gold, J ;

Kasemo, B .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2002, 24 (02) :155-170

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