自身免疫性甲状腺疾病临床研究进展

被引：18

作者：

张铮

郑旭琴

杨涛

机构：

[1] 南京医科大学第一附属医院

来源：

药品评价 | 2016年 / 13卷 / 01期

关键词：

自身免疫性甲状腺疾病; Graves病; 桥本甲状腺炎; 自身免疫病;

D O I：

暂无

中图分类号：

R581 [甲状腺疾病];

学科分类号：

100201 [内科学];

摘要：

自身免疫性甲状腺疾病(autoimmune thyroid disease,AITD)是一组T细胞介导器官特异性自身免疫病,临床上以Graves病(Graves'disease,GD)和桥本甲状腺炎(Hashimoto thyroiditis,HT)最为多见,分别以甲状腺功能亢进和甲状腺功能低下为特征。研究统计显示,全球AITD患病率接近5%,仅表现为抗甲状腺抗体阳性而无症状的亚临床AITD的比例会更高,尤其以30至40岁的女性多见。诱发自身免疫攻击甲状腺的机制很复杂,其中,遗传易感性和环境诱发因素是的相互作用认为是导致AITD发病的关键原因。另外,有数据显示,AITD与甲状腺肿瘤发生相关,因此,及时准确的诊治很有必要。本文将就A ITD的临床进展及诱导自身免疫病的免疫耐受思路进行简要介绍。

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页码：9 / 13

页数：5

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