A critical role for interleukin-1β in the progression of autoimmune diseases

被引：128

作者：

Zhao, Ruijuan ^{[1
]}

Zhou, Hongyan ^{[1
]}

Su, Shao Bo ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510060, Guangdong, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2013年 / 17卷 / 03期

关键词：

Interleukin-1; beta; Autoimmune diseases; Biological therapy; NF-KAPPA-B; IL-1 RECEPTOR ANTAGONIST; TUMOR-NECROSIS-FACTOR; SYSTEMIC-LUPUS-ERYTHEMATOSUS; INTERCELLULAR-ADHESION MOLECULE-1; PRIMARY SJOGRENS-SYNDROME; MESSENGER-RNA EXPRESSION; T-LYMPHOCYTE RESPONSE; NITRIC-OXIDE SYNTHASE; RHEUMATOID-ARTHRITIS;

D O I：

10.1016/j.intimp.2013.08.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Interleukin-1 beta (IL-1 beta) belongs to IL-1 family and is a potent pro-inflammatory cytokine. It is known to be also involved in a variety of cellular activities, including cell proliferation, differentiation and apoptosis. In addition to its pathophysiologic role in host protection, IL-1 beta promotes the progression of a number of autoimmune diseases. Most of such diseases can be controlled by anti-IL-1 beta treatment. This review discusses the contribution of IL-1 beta to the course of autoimmune diseases, such as rheumatic diseases, uveitis, autoimmune thyroid diseases (AITD), insulin-dependent diabetes mellitus (IDDM), autoimmune inner ear disease (AIED), multiple sclerosis (MS), myocarditis, hepatitis and kidney diseases. The critical involvement of IL-1 beta in the pathogenesis of autoimmune diseases provides targets for developing therapeutic treatment. (C) 2013 Elsevier B.V. All rights reserved.

引用

收藏

页码：658 / 669

页数：12

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