5-HT相关基因与自杀

被引:5
作者
张玉琦
李桂林
李克
机构
[1] 汕头大学医学院卫生学教研室
[2] 济宁医学院第二附属医院神经科
[3] 汕头大学医学院卫生学教研室 广东汕头
[4] 山东济宁
[5] 广东汕头
关键词
自杀; 5-HT; 基因;
D O I
暂无
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
家系调查、双生子和寄养子研究证明自杀存在明确的遗传因素。 5 HT功能异常与自杀行为有关 ,这在大多数的研究中已被证实。本文就 5 HT系统有关基因的遗传变异与自杀关联研究的现状作一综述
引用
收藏
页码:229 / 232
页数:4
相关论文
共 27 条
[21]  
No association between non-violent suicidal behavior and the serotonin transporter promoter polymorphism. Courtet P,Buresi C,Abbar M,et al. American Journal of Medical Genetics . 2003
[22]  
A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Mann JJ. Archives of General Psychiatry . 2000
[23]  
The serotonin receptor subtype 2 locus HTR2 is on human chromosome 13 near genes for esterase D and retinoblastoma-1 and on mouse chromosome 14. Hsieh CL,Bowcock AM,Farrer LA,et al. Somatic Cell Genetics . 1990
[24]  
Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder. Du L,Bakish D,Lapierre YD. American Journal of Medical Genetics . 2000
[25]  
The 5-HT(2A)receptor gene 102T C polymorphism is associated with suicidal behavior in depressed patients. Arias B,Gasto C,Catalan R. American Journal of Medical Genetics . 2001
[26]  
Lack of association of serotonin-2A receptor gene polymorphism(T102C)with suicidal ideation and suicide. Bondy B. American Journal of Medical Genetics . 2000
[27]  
Serotonin 2A receptor gene polymorphism is not associated with completed suicide. Ono H. Journal of Psychiatric Research . 2001