阿尔兹海默病患者睡眠脑电图分析

被引：7

作者：

严钢莉 ^{[1
]}

刘登华 ^{[2
]}

李朝武 ^{[1
]}

聂海岭 ^{[1
]}

黎逢光 ^{[1
]}

成勇 ^{[1
]}

毛高峰 ^{[1
]}

方煌 ^{[1
]}

魏海燕 ^{[1
]}

机构：

[1] 解放军中心医院神经内科

[2] 华中科技大学同济医学院附属同济医院神经内科

来源：

神经损伤与功能重建 | 2015年 / 10卷 / 03期

关键词：

阿尔兹海默病; 睡眠脑电图; 睡眠障碍;

D O I：

暂无

中图分类号：

R749.16 [];

学科分类号：

摘要：

目的:观察阿尔兹海默病(AD)患者夜间睡眠的临床特征。方法:对53例AD患者(AD组)和25例年龄、性别相匹配的健康体检者(对照组)进行夜间睡眠脑电图检测;同时将AD组患者进行MMSE评分,根据评分将AD组患者分为轻、中、重度痴呆,分析快速眼动(REM)睡眠时间减少程度与MMSE评分的相关性。结果:与对照组相比,AD组患者总觉醒时间增加,睡眠效率、睡眠潜伏期减少,REM睡眠比例下降,差异有统计学意义(P<0.05);AD患者痴呆程度越重,REM睡眠减少越显著。结论:AD患者睡眠指标和睡眠结构发生改变,表现为觉醒时间增加,睡眠效率、睡眠潜伏期减少,REM睡眠减少;痴呆程度越重,REM睡眠减少越显著。

引用

页码：210 / 212

页数：3

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