蛇床子素对人胶质瘤U251细胞抗增殖作用的研究

被引：6

作者：

王洁 ^{[1
]}

安静 ^{[2
]}

顾云利 ^{[3
]}

张娟 ^{[3
]}

何瑞 ^{[3
]}

机构：

[1] 郑州市儿童医院外科ICU

[2] 第四军医大学西京医院NSICU

[3] 榆林市第一医院神经外科

来源：

现代生物医学进展 | 2013年 / 13卷 / 11期

关键词：

蛇床子素; 凋亡; 细胞周期; U251细胞;

D O I：

10.13241/j.cnki.pmb.2013.11.011

中图分类号：

R285.5 [中药实验药理]; R739.4 [神经系肿瘤];

学科分类号：

100115 [医学神经生物学]; 100806 [中药药理学];

摘要：

目的:研究蛇床子素对人胶质瘤U251细胞的抗增殖作用和可能的机制。方法:不同浓度蛇床子素处理U251细胞后,MTT法检测细胞活力,流式细胞法检测细胞周期和凋亡情况。结果:①蛇床子素显著抑制U251细胞的增殖。②蛇床子素诱导U251细胞发生G2/M期阻滞和凋亡。③蛇床子素处理后的U251细胞PI3K/Akt信号通路活性受到明显抑制。结论:蛇床子素通过抑制PI3K/Akt信号通路抑制人胶质瘤U251细胞的增殖。

引用

页码：2065 / 2067+2130 +2130

页数：4

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