他汀类血脂调节药的药理及研究进展

被引：4

作者：

傅得兴

机构：

[1] 卫生部北京医院药剂科

来源：

引进国外医药技术与设备 | 1999年 / 06期

关键词：

血脂; 冠心病; 羟甲戊二酰辅酶A还原酶; 他汀类药; 药理作用;

D O I：

暂无

中图分类号：

R969 [临床药理学];

学科分类号：

100602 ; 100706 ;

摘要：

本文通过文献检索综述了他汀类血脂调节药的药理作用及研究进展。该类药物选择性抑制羟甲戊二酰辅酶A(HMG-CoA)还原酶,降低血中胆固醇水平,增加肝细胞表面低密度脂蛋白的受体数目。他汀类药物不仅能降低低密度脂蛋白胆固醇和甘油三酯,升高高密度脂蛋白胆固醇水平,而且能降低冠心病事件发生率及死亡率,具有抗动脉粥样硬化作用。他汀类药物的开发和应用,开启了冠心病防治的新纪元。

引用

页码：55 / 59

页数：5

共 10 条

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