邻苯二甲酸二丁酯的毒性作用及机制

被引：27

作者：

纪红蕊

杜霞

宋永彬

刘欣

机构：

[1] 哈尔滨理工大学化学与环境工程学院

来源：

沈阳工业大学学报 | 2017年 / 39卷 / 02期

关键词：

邻苯二甲酸二丁酯; 肝脏毒性; 生殖毒性; 脂质过氧化损伤; 血-睾屏障; 精子活力; 精子畸形率; 病理改变;

D O I：

暂无

中图分类号：

R114 [卫生毒理];

学科分类号：

100235 [预防医学];

摘要：

针对环境污染日益严重的现状,探讨了邻苯二甲酸二丁酯(DBP)的肝脏与生殖毒性作用.检测了血浆和肝脏中的关键酶、精子活动力与畸形率,观察了肝脏和睾丸的病理改变.结果表明,DBP可以显著升高谷丙转氨酶(GPT)、谷草转氨酶(GOT)、碱性磷酸酶(AKP)和丙二醛(MDA),显著降低超氧化物歧化酶(SOD)和过氧化氢酶(CAT),表明DBP会诱发小鼠肝脏发生脂质过氧化过程,引起早期的肝脏损伤.DBP能够穿透血-睾屏障,干扰精子的生长和发育过程.因此,DBP是一种对雄性生殖细胞具有潜在诱变危害的遗传毒性化合物.

引用

收藏

页码：230 / 235

页数：6

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