原发性卵巢功能不全与卵巢早衰的病因学研究进展

被引：13

作者：

陈子江 ^{[1
]}

秦莹莹 ^{[1
]}

Simpson JL ^{[2
]}

机构：

[1] 山东大学附属省立医院生殖医学中心

[2] College of Medicine Miami,Florida International

来源：

中华妇产科杂志 | 2008年 / 12期

关键词：

D O I：

暂无

中图分类号：

R686 [筋腱、韧带、滑囊疾病及损伤];

学科分类号：

摘要：

<正> 目前,卵巢早衰(premature ovarian failure,POF)是被广泛接受和应用的专业术语,通常是指女性40岁之前闭经,伴有高卵泡刺激素(FSH)和低雌激素水平。由于临床治疗很棘手,如何预防和预测POF 的发生风险,成为临床医生关注的焦点。尽管在 POF 发病机制的探讨中,染色体结构或数目异常、自身免疫功能、医源性及环境等相关因素与 POF发病的相关性研究已取得很大进展,但仍有部分POF 患者的病因不清,称为"特发性 POF"。

引用

共 11 条

[1] Estrogen receptor α gene polymorphisms are associated with idiopathic premature ovarian failure [J].

Bretherick, Karla L. ;

Hanna, Courtney W. ;

Currie, Lauren M. ;

Fluker, Margo R. ;

Hammond, Geoffrey L. ;

Robinson, Wendy P. .

FERTILITY AND STERILITY, 2008, 89 (02) :318-324

[2] Analysis of LHX8 mutation in premature ovarian failure [J].

Qin, Yingying ;

Zhao, Han ;

Kovanci, Ertug ;

Simpson, Joe Leigh ;

Chen, Zi-Jiang ;

Rajkovic, Aleksandar .

FERTILITY AND STERILITY, 2008, 89 (04) :1012-1014

[3] Transcription factor FIGLA is mutated in patients with Premature Ovarian Failure [J].

Zhao, Han ;

Chen, Zi-Jiang ;

Qin, Yingying ;

Shi, Yuhua ;

Wang, Shan ;

Choi, Youngsok ;

Simpson, Joe Leigh ;

Rajkovic, Aleksandar .

AMERICAN JOURNAL OF HUMAN GENETICS, 2008, 82 (06) :1342-1348

[4]

Spontaneous premature ovarian failure: Management challenges[J] . Emmanuel Kalu,Nick Panay.Gynecological Endocrinology . 2008 (5)

[5] Gonadotropin-releasing hormone analog treatment for the prevention of treatment-related ovarian failure and infertility in women of reproductive age with Hodgkin lymphoma [J].

Falorio, Simona ;

Angrilli, Francesco ;

Fioritoni, Giuseppe .

LEUKEMIA & LYMPHOMA, 2008, 49 (06) :1087-1093

[6] Analyses of GDF9 mutation in 100 Chinese women with premature ovarian failure [J].

Zhao, Han ;

Qin, Yingying ;

Kovanci, Ertug ;

Simpson, Joe Leigh ;

Chen, Zi-Jiang ;

Rajkovic, Aleksandar .

FERTILITY AND STERILITY, 2007, 88 (05) :1474-1476

[7] NOBOX homeobox mutation causes premature ovarian failure [J].

Qin, Yingying ;

Choi, Youngsok ;

Zhao, Han ;

Simpson, Joe Leigh ;

Chen, Zi-Jiang ;

Rajkovic, Aleksandar .

AMERICAN JOURNAL OF HUMAN GENETICS, 2007, 81 (03) :576-581

[8]

A novel polyalanine expansion in FOXL2: the first evidence for a recessive form of the blepharophimosis syndrome （BPES） associated with ovarian dysfunction[J] . Jeyabalan Nallathambi,Lara Moumné,Elfride Baere,Diane Beysen,Kim Usha,Periasamy Sundaresan,Reiner A. Veitia.Human Genetics . 2007 (1)

[9]

Isolated 17,20-lyase （desmolase） deficiency in a 46,XX female presenting with delayed puberty[J] . Enver Simsek,Ismail Ozdemir,Lin Lin,John C. Achermann.Fertility and Sterility . 2005 (5)

[10]

Parkinsonism, premature menopause, and mitochondrial DNA polymerase γ mutations: clinical and molecular genetic study[J] . Petri Luoma,Atle Melberg,Juha O Rinne,Jyrki A Kaukonen,Nina N Nupponen,Richard M Chalmers,Anders Oldfors,Ilkka Rautakorpi,Leena Peltonen,Kari Majamaa,Hannu Somer,Anu Suomalainen.The Lancet . 2004 (9437)

← 1 2 →