附子配伍干姜治疗心力衰竭的药理作用及机制研究进展

被引：51

作者：

文建霞 ^{[1
,2
]}

王建 ^{[1
]}

张璐 ^{[1
,2
]}

陆小华 ^{[1
,2
]}

魏士长 ^{[1
,2
]}

李浩田 ^{[2
]}

赵艳玲 ^{[2
]}

机构：

[1] 成都中医药大学药学院中药材标准化教育部重点实验室

[2] 中国人民解放军总医院第五医学中心药学部

来源：

中国医院用药评价与分析 | 2019年 / 19卷 / 10期

关键词：

附子; 干姜; 心力衰竭; 研究进展;

D O I：

10.14009/j.issn.1672-2124.2019.10.004

中图分类号：

R285.5 [中药实验药理];

学科分类号：

100806 [中药药理学];

摘要：

附子配伍干姜是古今临床常用药对,二者配伍协同发挥回阳救逆、温中散寒的功效。心力衰竭为各种心脏疾病的严重和终末阶段,发病率高,是目前最重要的心血管病之一。现代研究结果发现,附子配伍干姜有明显抗心力衰竭的作用。本研究通过查阅文献,分别从血流动力学、神经内分泌系统、衰竭心脏的代谢性重构、血管内皮细胞、离子通道和心肌细胞凋亡等方面综述附子配伍干姜治疗心力衰竭的药理作用,并对其潜在作用机制进行分析,以期为附子配伍干姜治疗心力衰竭的临床应用提供参考和依据。

引用

页码：1167 / 1170

页数：4

共 39 条

[1]

养心通脉方对异丙肾上腺素心衰大鼠防治机理的研究 [D].

朱智德 .

湖北中医药大学,

2012

[2]

CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy.[J].Bence Hegyi;Donald M. Bers;Julie Bossuyt.Journal of Molecular and Cellular Cardiology.2019,

[3]

Orchestrating Metabolic Flexibility: PGC-1α and Clinical Heart Failure [J].

Joseph, Jacob .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2019, 357 (04) :273-274

[4]

Protective Effects of Nicorandil on Cardiac Function and Left Ventricular Remodeling in a Rat Model of Ischemic Heart Failure [J].

Xing, Yanqiu ;

Liu, Congcong ;

Wang, Huanliang ;

Zhang, Xia ;

Wang, Yan ;

Yue, Xizan ;

Li, Zhonggang ;

Wang, Xin ;

Zhang, Wenhua .

ARCHIVES OF MEDICAL RESEARCH, 2018, 49 (08) :583-587

[5]

Increased Cardiac Uptake of Ketone Bodies and Free Fatty Acids in Human Heart Failure and Hypertrophic Left Ventricular Remodeling [J].

Voros, Gabor ;

Ector, Joris ;

Garweg, Christophe ;

Droogne, Walter ;

Van Cleemput, Johan ;

Peersman, Nele ;

Vermeersch, Pieter ;

Janssens, Stefan .

CIRCULATION-HEART FAILURE, 2018, 11 (12) :e004953

[6]

Zingiberis rhizoma mediated enhancement of the pharmacological effect of aconiti lateralis radix praeparata against acute heart failure and the underlying biological mechanisms.[J].Lu Zhang;Xiaohua Lu;Jiabo Wang;Pengyan Li;Haotian Li;Shizhang Wei;Xuelin Zhou;Kun Li;Lifu Wang;Ruilin Wang;Yanling Zhao;Xiaohe Xiao.Biomedicine & Pharmacotherapy.2017,

[7]

The protective effects of compatibility of Aconiti Lateralis Radix Praeparata and Zingiberis Rhizoma on rats with heart failure by enhancing mitochondrial biogenesis via Sirt1/PGC-1α pathway.[J].Xiaohua Lu;Lu Zhang;Pengyan Li;Jiabo Wang;Ruisheng Li;Yinqiu Huang;Mingquan Wu;Houqin Zhou;Yang Li;Shizhang Wei;Kun Li;Haotian Li;Xuelin Zhou;Yanling Zhao;Xiaohe Xiao.Biomedicine & Pharmacotherapy.2017,

[8]

Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity.[J].Dunja Aksentijević;Debra J. McAndrew;Anja Karlstädt;Sevasti Zervou;Liam Sebag-Montefiore;Rebecca Cross;Gillian Douglas;Vera Regitz-Zagrosek;Gary D. Lopaschuk;Stefan Neubauer;Craig A. Lygate.Journal of Molecular and Cellular Cardiology.2014,

[9]

Heterogeneous Upregulation of Apamin-Sensitive Potassium Currents in Failing Human Ventricles [J].

Chang, Po-Cheng ;

Turker, Isik ;

Lopshire, John C. ;

Masroor, Saqib ;

Nguyen, Bich-Lien ;

Tao, Wen ;

Rubart, Michael ;

Chen, Peng-Sheng ;

Chen, Zhenhui ;

Ai, Tomohiko .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2013, 2 (01) :e004713

[10]

Research on Fuzi based on animal thermotropism behavior to discover if it has fewer "hot" characteristics without Ganjiang [J].

Sun Zhi-yong ;

Zhao Yan-ling ;

Wang Jia-bo ;

Zhang Lin ;

Wei Si-si ;

Jiang Feng-juan ;

Jia Lei ;

Cheng Dan-hong ;

Xiao Xiao-he .

JOURNAL OF TRADITIONAL CHINESE MEDICINE, 2012, 32 (02) :208-214

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