关节软骨含水率变化与骨关节炎筋骨失养的关系探讨

被引：5

作者：

陈后煌 ^{[1
]}

邵翔 ^{[1
]}

郑文伟 ^{[2
]}

马玉环 ^{[2
]}

陈达 ^{[1
]}

叶蕻芝 ^{[3
]}

李西海 ^{[1
]}

机构：

[1] 福建中医药大学中西医结合研究院

[2] 福建中医药大学药学院

[3] 福建省中西医结合老年性疾病重点实验室

来源：

风湿病与关节炎 | 2016年 / 5卷 / 10期

关键词：

骨关节炎; 含水率; 软骨; 筋骨失养;

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

骨关节炎病在筋骨,筋骨失养为主要病理表现,常见于中老年人,软骨退变在骨关节炎筋骨失养过程中发挥重要作用。水占关节软骨湿重的80%,是软骨所需营养物质的重要媒介,在关节软骨生化组成中所占比重最大,水与胶原纤维及蛋白多糖相结合共同提供了软骨细胞生物学功能的内环境,与软骨生物力学功能密切相关。调节含水率可能是延缓或阻止软骨退变的重要机制之一,提示有效调控关节软骨含水率在骨关节炎形成和发展中的作用,对骨关节炎筋骨失养的防治研究具有重要意义。

引用

收藏

页码：51 / 54

页数：4

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