自噬与PI3K-AKT/mTOR信号通路在足细胞损伤中的研究进展

被引：35

作者：

于子凯

李刘生

张昱

机构：

[1] 中国中医科学院西苑医院

来源：

中国医药导报 | 2016年 / 13卷 / 09期

关键词：

足细胞; 自噬; 信号通路; 肾脏病;

D O I：

暂无

中图分类号：

R692 [肾疾病];

学科分类号：

100221 [泌尿外科学];

摘要：

自噬是广泛存在于真核细胞中的生命现象,是生物体在其发育、老化过程中都存在的一个净化自身多余或受损细胞器的共同机制,生命体通过自噬清除细胞废物、进行结构重建以维持蛋白代谢平衡及细胞环境稳定。足细胞是肾脏固有细胞,其损伤是导致肾病蛋白尿和肾小球硬化的重要原因。PI3K-Akt/m TOR是广泛存在于足细胞内的重要信号通路,对足细胞自噬有一定调控作用。本文旨在对PI3K-Akt/m TOR信号通路与足细胞自噬的关系进行综述,以期探讨足细胞损伤所致肾病蛋白尿和肾小球硬化的治疗靶点。

引用

页码：84 / 87

页数：4

共 18 条

[1]

Growth Hormone Induces Transforming Growth Factor-Beta-Induced Protein in Podocytes: Implications for Podocyte Depletion and Proteinuria [J].

Chitra, P. Swathi ;

Swathi, T. ;

Sahay, Rakesh ;

Reddy, G. Bhanuprakash ;

Menon, Ram K. ;

Kumar, P. Anil .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2015, 116 (09) :1947-1956

[2]

Protective role of cyclosporine A and minocycline on mitochondrial disequilibrium-related podocyte injury and proteinuria occurrence induced by adriamycin [J].

Guan, Na ;

Ren, Ya-Li ;

Liu, Xiao-Ya ;

Zhang, Ying ;

Pei, Pei ;

Zhu, Sai-Nan ;

Fan, Qingfeng .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2015, 30 (06) :957-969

[3]

Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization [J].

Liu, Kun ;

Zhao, Enpeng ;

Ilyas, Ghulam ;

Lalazar, Gadi ;

Lin, Yu ;

Haseeb, Muhammad ;

Tanaka, Kathryn E. ;

Czaja, Mark J. .

AUTOPHAGY, 2015, 11 (02) :271-284

[4]

Autophagy and Immune Response in Kidneys [J].

Leventhal, Jeremy S. ;

He, John C. ;

Ross, Michael J. .

SEMINARS IN NEPHROLOGY, 2014, 34 (01) :53-61

[5]

Inhibition of the mTOR pathway: A possible protective role in coronary artery disease [J].

Tarantino, Giovanni ;

Capone, Domenico .

ANNALS OF MEDICINE, 2013, 45 (04) :348-356

[6]

mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice [J].

Inoki, Ken ;

Mori, Hiroyuki ;

Wang, Junying ;

Suzuki, Tsukasa ;

Hong, SungKi ;

Yoshida, Sei ;

Blattner, Simone M. ;

Ikenoue, Tsuneo ;

Rueegg, Markus A. ;

Hall, Michael N. ;

Kwiatkowski, David J. ;

Rastaldi, Maria P. ;

Huber, Tobias B. ;

Kretzler, Matthias ;

Holzman, Lawrence B. ;

Wiggins, Roger C. ;

Guan, Kun-Liang .

JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (06) :2181-2196

[7]

mTOR upregulation of glycolytic enzymes promotes tumor development [J].

Zha, Xiaojun ;

Sun, Qian ;

Zhang, Hongbing .

CELL CYCLE, 2011, 10 (07) :1015-1016

[8]

The glomerulus – a view from the outside – the podocyte.[J].Huifang Cheng;Raymond C. Harris.International Journal of Biochemistry and Cell Biology.2010, 9

[9]

mTOR regulation of autophagy [J].