慢性阻塞性肺疾病病因及发病机制研究进展

被引：282

作者：

肖建

杜春玲

机构：

[1] 复旦大学附属中山医院青浦分院呼吸内科

来源：

中国老年学杂志 | 2014年 / 34卷 / 11期

关键词：

慢性阻塞性肺疾病; 空气污染; 感染;

D O I：

暂无

中图分类号：

R563.9 [其他];

学科分类号：

100201 [内科学];

摘要：

<正>基于世界卫生组织(WHO)所提供的数据,到2020年慢性阻塞性肺疾病(COPD)将成为死亡率第3位的疾病〔1,2〕。COPD的病因及发病机制目前仍不完全清楚,其发病与多种因素有关。引起COPD最主要的危险因素包括吸烟、环境污染、职业性粉尘和化学物质接触、感染、遗传因素等〔3〕。1 COPD病因的研究1.1吸烟吸烟是目前最常见的导致COPD的危险因素。与不吸烟者相比,吸烟者出现呼吸道症状和肺功能异常的概率更

引用

页码：3191 / 3194

页数：4

共 24 条

[1]

ATP and the pathogenesis of COPD.[J].Esmaeil Mortaz;Gert Folkerts;Frans P. Nijkamp;Paul A.J. Henricks.European Journal of Pharmacology.2010, 1

[2]

Translating the COPD transcriptome: insights into pathogenesis and tools for clinical management..[J].Zeskind Julie E;Lenburg Marc E;Spira Avrum.Proceedings of the American Thoracic Society.2008, 8

[3]

The role of atypical respiratory pathogens in exacerbations of chronic obstructive pulmonary disease [J].

Diederen, B. M. W. ;

van der Valk, P. D. L. P. M. ;

Kluytmans, J. A. W. J. ;

Peeters, M. F. ;

Hendrix, R. .

EUROPEAN RESPIRATORY JOURNAL, 2007, 30 (02) :240-244

[4]

Akt in the pathogenesis of COPD..[J].Bozinovski Steven;Vlahos Ross;Hansen Michelle;Liu Ken;Anderson Gary P.International journal of chronic obstructive pulmonary disease.2006, 1

[5]

Chemokine receptors in chronic obstructive pulmonary disease (COPD) [J].

Panina, Paola ;

Mariani, Margherita ;

D'Ambrosio, Daniele .

CURRENT DRUG TARGETS, 2006, 7 (06) :669-674

[6]

The role of vagal afferent nerves in chronic obstructive pulmonary disease..[J].Undem Bradley J;Kollarik Marian.Proceedings of the American Thoracic Society.2005, 4

[7]

Steroid-resistant inflammation in a rat model of chronic obstructive pulmonary disease is associated with a lack of nuclear factor-kappaB pathway activation..[J].Birrell Mark A;Wong Sissie;Hele David J;McCluskie Kerryn;Hardaker Elizabeth;Belvisi Maria G.American journal of respiratory and critical care medicine.2005, 1

[8]

Pathogenesis of COPD [J].