茵陈蒿汤防治肝脏疾病的药理作用及药动学研究进展

被引：49

作者：

王晶 ^{[1
]}

欧阳冰琛 ^{[2
]}

机构：

[1] 南京中医药大学附属南京中医院药学部

[2] 南京中医药大学附属医院临床药理科

来源：

药物评价研究 | 2021年 / 44卷 / 03期

关键词：

茵陈蒿汤; 肝保护; 药理作用; 药动学;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

100806 [中药药理学];

摘要：

茵陈蒿汤源自《伤寒论》,为治疗湿热黄疸的经典方剂。药理研究发现其对多种类型肝损伤具有保护作用,可用于胆汁淤积、非酒精性脂肪肝、酒精性脂肪肝、肝纤维化、肝硬化的治疗,肝保护机制为调节胆红素胆汁酸代谢、降脂降糖、抗氧化、抑制肝星状细胞增殖和活化、抑制肝细胞凋亡、抗炎、调节肠道菌群。对茵陈蒿汤的药动学研究日渐增多,肝损伤对其药动学行为产生一定影响。综述茵陈蒿汤在肝脏疾病防治中的药理作用和药动学特征,为该方剂的开发应用和临床合理使用提供依据。

引用

页码：628 / 637

页数：10

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