白藜芦醇对阿霉素诱导心脏毒性保护作用的研究进展

被引：8

作者：

张蕊

马寅仲

孙双勇

郝春华

赵专友

王维亭

机构：

[1] 天津药物研究院新药评价有限公司

来源：

现代药物与临床 | 2017年 / 32卷 / 04期

关键词：

白藜芦醇; 阿霉素; 心脏毒性; 保护作用;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100706 [药理学];

摘要：

阿霉素是多种血液恶性肿瘤和实体瘤的主要治疗药物。然而,其临床应用受剂量相关性心脏毒性的限制。阿霉素诱导心脏毒性的机制可能涉及多种信号通路,包括自由基产生、钙超载、线粒体功能障碍、细胞凋亡和自噬。已有研究表明白藜芦醇与阿霉素联合用药可以预防心脏毒性,并且对肿瘤细胞发挥协同治疗效应。主要对白藜芦醇的心脏毒性保护作用进行综述,阐明白藜芦醇在阿霉素诱导心脏毒性中保护作用的机制。

引用

页码：752 / 756

页数：5

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