凝胶渗透色谱-液相色谱-串联质谱法同时测定化妆品中15种糖皮质激素和性激素

被引:27
作者
崔晗
沈葆真
陈溪
曹文军
刘梦遥
黄大亮
机构
[1] 大连出入境检验检疫局
关键词
化妆品; 糖皮质激素; 性激素; 凝胶渗透色谱; 液相色谱-串联质谱;
D O I
10.13218/j.cnki.csdc.2014.05.066
中图分类号
O657.63 [质谱分析]; TQ658 [化妆品];
学科分类号
070302 [分析化学]; 080501 [材料物理与化学];
摘要
建立了一种凝胶渗透色谱-液相色谱-串联质谱法同时测定化妆品中15种糖皮质激素和性激素的方法。化妆品样品采用乙腈超声提取,环己烷-乙酸乙酯体系的凝胶渗透色谱柱净化,以乙腈-体积分数为0.1%甲酸水溶液作为流动相,经C18色谱柱进行分离,由液相色谱-串联质谱仪定量检测。结果表明,方法的线性关系良好,相关系数R均大于0.995,方法检出限为0.1~4.0 mg·kg-1,添加平均回收率为70.0%104.0%,相对标准偏差为5.3%15.5%。
引用
收藏
页码:295 / 298
页数:4
相关论文
共 7 条
[1]
Determination of estrogens in water by HPLC–UV using cloud point extraction.[J].Ling Wang;Ya-Qi Cai;Bin He;Chun-Gang Yuan;Da-Zhong Shen;Jing Shao;Gui-Bin Jiang.Talanta.2006, 1
[2]
Effect of the systemic versus inhalatory administration of synthetic glucocorticoids on the urinary steroid profile as studied by gas chromatography–mass spectrometry.[J].Monica Mazzarino;Francesca Rossi;Laura Giacomelli;Francesco Botrè.Analytica Chimica Acta.2005, 1
[3]
Detection of synthetic glucocorticoid residues in cattle tissue and hair samples after a single dose administration using LC–MS/MS.[J].Olivia Van den hauwe;Frederic Dumoulin;Chris Elliott;Carlos Van Peteghem.Journal of Chromatography B.2004, 2
[4]
Simultaneous determination of anabolic steroids and synthetic hormones in meat by freezing-lipid filtration; solid-phase extraction and gas chromatography–mass spectrometry.[J].Jungju Seo;Hye-Young Kim;Bong Chul Chung;Jongki Hong.Journal of Chromatography A.2004, 1
[5]
Determination of natural and synthetic estrogens in water by gas chromatography with mass spectrometric detection.[J]..Journal of Chromatography A.2003, 1
[6]
亚临界1;1;1;2-四氟乙烷萃取-气相色谱-质谱法测定鱼肉中6种性激素残留.[J].卢杰;冯晓梅;隋晓;陈曼华;韩玉谦;薛长湖;.分析化学.2013, 10
[7]
超高效液相色谱-串联电喷雾四极杆质谱法同时测定牛奶中12种糖皮质激素的残留 [J].
崔晓亮 ;
邵兵 ;
赵榕 ;
孟娟 ;
涂晓明 .
色谱, 2006, (03) :213-217