药物代谢组学研究进展

被引：43

作者：

黄寅 ^{[1
]}

许风国 ^{[1
,2
]}

张伟 ^{[3
]}

王俊南 ^{[4
]}

张尊建 ^{[1
,2
]}

机构：

[1] 中国药科大学药物质量与安全预警教育部重点实验室

[2] 中国药科大学天然药物活性组分与药效国家重点实验室

[3] 澳门科技大学中药质量研究国家重点实验室

[4] 新加坡国立大学公共卫生学院

来源：

中国药科大学学报 | 2013年 / 44卷 / 02期

关键词：

药物代谢组学; 系统生物学; 代谢通路; 生物标记物;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100706 [药理学];

摘要：

药物代谢组学是在系统生物学背景下,代谢组学与药学紧密交叉、有机结合促生的一门新兴学科。它依托现代分析技术、化学计量学和生物信息学技术,通过分析比较给药前后生物体液中小分子代谢物轮廓的改变来进行药物疗效和毒性的评价、预测。本文对药物代谢组学的研究流程和应用等方面的最新进展进行了系统概括,并对相关技术要点和存在的问题进行了讨论。

引用

收藏

页码：105 / 112

页数：8

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