学术探索
学术期刊
学术作者
新闻热点
数据分析
智能评审
脓毒症早期诊断生化标志物的研究进展
被引:12
作者
:
论文数:
引用数:
h-index:
机构:
王洪霞
论文数:
引用数:
h-index:
机构:
陈兵
机构
:
[1]
天津医科大学第二医院急诊科
来源
:
医学综述
|
2011年
/ 17卷
/ 15期
关键词
:
脓毒症;
生化标志物;
诊断;
D O I
:
暂无
中图分类号
:
R459.7 [急症、急救处理];
学科分类号
:
100231
[临床病理学]
;
摘要
:
脓毒症与非感染性全身炎性反应综合征有着相似的临床表现,早期诊断脓毒症至关重要。脓毒症诊断中常用的生化标志物C反应蛋白是非特异性炎症指标,白细胞介素6是重要的细胞因子,在脓毒症时升高,但特异性不高。降钙素原在脓毒症中的诊断价值存在争议,B型尿钠肽前体N末端水平在严重脓毒症时可作为一个早期心功能障碍和心肌抑制有用的生物指标。肾上腺髓质素前体中段、内皮素1前体、髓样细胞触发受体(TREM-1)是新近发现的炎症指标,尤其是sTREM-1可能成为诊断脓毒症最有前途的生化标志物。
引用
收藏
页码:2256 / 2258
页数:3
相关论文
共 6 条
[1]
Role of Endothelin1in the Pathogenesis of Chronic Chagasic Heart Disease..Tanowitz HB;Huang H;Jelicks LA;et al;.Infect Immun.2005,
[2]
Serum of patients with septic shock stimulates the expression of Trem-1 on U937 monocytes
[J].
Dimopoulou, I.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Athens, Sch Med, Dept Crit Care Med 2, GR-10679 Athens, Greece
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Dimopoulou, I.
;
Orfanos, S. E.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Athens, Sch Med, Dept Crit Care Med 2, GR-10679 Athens, Greece
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Orfanos, S. E.
;
Pelekanou, A.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Pelekanou, A.
;
Kotanidou, A.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Athens, Sch Med, Dept Crit Care Med 1, GR-10679 Athens, Greece
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Kotanidou, A.
;
Livaditi, O.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Athens, Sch Med, Dept Crit Care Med 1, GR-10679 Athens, Greece
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Livaditi, O.
;
Augustatou, C.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Athens, Sch Med, Dept Crit Care Med 2, GR-10679 Athens, Greece
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Augustatou, C.
;
Zervou, M.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Athens, Sch Med, Dept Crit Care Med 2, GR-10679 Athens, Greece
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Zervou, M.
;
Douka, E.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Athens, Sch Med, Dept Crit Care Med 2, GR-10679 Athens, Greece
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Douka, E.
;
Theodorakopoulou, M.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Athens, Sch Med, Dept Crit Care Med 2, GR-10679 Athens, Greece
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Theodorakopoulou, M.
;
Karagianni, V.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Karagianni, V.
;
Douzinas, E.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Athens, Sch Med, Dept Crit Care Med 3, GR-10679 Athens, Greece
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Douzinas, E.
;
Armaganidis, A.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Athens, Sch Med, Dept Crit Care Med 2, GR-10679 Athens, Greece
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Armaganidis, A.
;
Giamarellos-Bourboulis, E. J.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Giamarellos-Bourboulis, E. J.
.
INFLAMMATION RESEARCH,
2009,
58
(03)
:127
-132
[3]
Prognostic value of plasma N-terminal pro-brain natriuretic peptide in patients with severe sepsis
[J].
Brueckmann, M
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Heidelberg, Dept Med 1, Fac Clin Med Mannheim, D-68167 Mannheim, Germany
Brueckmann, M
;
Huhle, G
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Heidelberg, Dept Med 1, Fac Clin Med Mannheim, D-68167 Mannheim, Germany
Huhle, G
;
Lang, S
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Heidelberg, Dept Med 1, Fac Clin Med Mannheim, D-68167 Mannheim, Germany
Lang, S
;
Haase, KK
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Heidelberg, Dept Med 1, Fac Clin Med Mannheim, D-68167 Mannheim, Germany
Haase, KK
;
Bertsch, T
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Heidelberg, Dept Med 1, Fac Clin Med Mannheim, D-68167 Mannheim, Germany
Bertsch, T
;
Weiss, C
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Heidelberg, Dept Med 1, Fac Clin Med Mannheim, D-68167 Mannheim, Germany
Weiss, C
;
Kaden, JJ
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Heidelberg, Dept Med 1, Fac Clin Med Mannheim, D-68167 Mannheim, Germany
Kaden, JJ
;
Putensen, C
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Heidelberg, Dept Med 1, Fac Clin Med Mannheim, D-68167 Mannheim, Germany
Putensen, C
;
Borggrefe, M
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Heidelberg, Dept Med 1, Fac Clin Med Mannheim, D-68167 Mannheim, Germany
Borggrefe, M
;
Hoffmann, U
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Heidelberg, Dept Med 1, Fac Clin Med Mannheim, D-68167 Mannheim, Germany
Hoffmann, U
.
CIRCULATION,
2005,
112
(04)
:527
-534
[4]
Proteolytic processing pattern of the endothelin-1 precursor in vivo
[J].
Struck, J
论文数:
0
引用数:
0
h-index:
0
机构:
BRAHMS Aktiengesell, Res Dept, D-16761 Hennigsdorf, Germany
BRAHMS Aktiengesell, Res Dept, D-16761 Hennigsdorf, Germany
Struck, J
;
Morgenthaler, NG
论文数:
0
引用数:
0
h-index:
0
机构:
BRAHMS Aktiengesell, Res Dept, D-16761 Hennigsdorf, Germany
BRAHMS Aktiengesell, Res Dept, D-16761 Hennigsdorf, Germany
Morgenthaler, NG
;
Bergmann, A
论文数:
0
引用数:
0
h-index:
0
机构:
BRAHMS Aktiengesell, Res Dept, D-16761 Hennigsdorf, Germany
BRAHMS Aktiengesell, Res Dept, D-16761 Hennigsdorf, Germany
Bergmann, A
.
PEPTIDES,
2005,
26
(12)
:2482
-2486
[5]
Time-course of sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin, and C-reactive protein plasma concentrations during sepsis
[J].
Gibot, S
论文数:
0
引用数:
0
h-index:
0
机构:
Hop Cent, Serv Reanimat Med, Nancy, France
Hop Cent, Serv Reanimat Med, Nancy, France
Gibot, S
;
Cravoisy, A
论文数:
0
引用数:
0
h-index:
0
机构:
Hop Cent, Serv Reanimat Med, Nancy, France
Cravoisy, A
;
Kolopp-Sarda, MN
论文数:
0
引用数:
0
h-index:
0
机构:
Hop Cent, Serv Reanimat Med, Nancy, France
Kolopp-Sarda, MN
;
Béné, MC
论文数:
0
引用数:
0
h-index:
0
机构:
Hop Cent, Serv Reanimat Med, Nancy, France
Béné, MC
;
Faure, G
论文数:
0
引用数:
0
h-index:
0
机构:
Hop Cent, Serv Reanimat Med, Nancy, France
Faure, G
;
Bollaert, PE
论文数:
0
引用数:
0
h-index:
0
机构:
Hop Cent, Serv Reanimat Med, Nancy, France
Bollaert, PE
;
Levy, B
论文数:
0
引用数:
0
h-index:
0
机构:
Hop Cent, Serv Reanimat Med, Nancy, France
Levy, B
.
CRITICAL CARE MEDICINE,
2005,
33
(04)
:792
-796
[6]
Comparison of procalcitonin and C-reactive protein as markers of sepsis
[J].
Luzzani, A
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Hosp, Inst Anesthesiol & Intens Care, Verona, Italy
Univ Hosp, Inst Anesthesiol & Intens Care, Verona, Italy
Luzzani, A
;
Polati, E
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Hosp, Inst Anesthesiol & Intens Care, Verona, Italy
Polati, E
;
Dorizzi, R
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Hosp, Inst Anesthesiol & Intens Care, Verona, Italy
Dorizzi, R
;
Rungatscher, A
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Hosp, Inst Anesthesiol & Intens Care, Verona, Italy
Rungatscher, A
;
Pavan, R
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Hosp, Inst Anesthesiol & Intens Care, Verona, Italy
Pavan, R
;
Merlini, A
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Hosp, Inst Anesthesiol & Intens Care, Verona, Italy
Merlini, A
.
CRITICAL CARE MEDICINE,
2003,
31
(06)
:1737
-1741
←
1
→
共 6 条
[1]
Role of Endothelin1in the Pathogenesis of Chronic Chagasic Heart Disease..Tanowitz HB;Huang H;Jelicks LA;et al;.Infect Immun.2005,
[2]
Serum of patients with septic shock stimulates the expression of Trem-1 on U937 monocytes
[J].
Dimopoulou, I.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Athens, Sch Med, Dept Crit Care Med 2, GR-10679 Athens, Greece
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Dimopoulou, I.
;
Orfanos, S. E.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Athens, Sch Med, Dept Crit Care Med 2, GR-10679 Athens, Greece
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Orfanos, S. E.
;
Pelekanou, A.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Pelekanou, A.
;
Kotanidou, A.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Athens, Sch Med, Dept Crit Care Med 1, GR-10679 Athens, Greece
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Kotanidou, A.
;
Livaditi, O.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Athens, Sch Med, Dept Crit Care Med 1, GR-10679 Athens, Greece
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Livaditi, O.
;
Augustatou, C.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Athens, Sch Med, Dept Crit Care Med 2, GR-10679 Athens, Greece
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Augustatou, C.
;
Zervou, M.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Athens, Sch Med, Dept Crit Care Med 2, GR-10679 Athens, Greece
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Zervou, M.
;
Douka, E.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Athens, Sch Med, Dept Crit Care Med 2, GR-10679 Athens, Greece
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Douka, E.
;
Theodorakopoulou, M.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Athens, Sch Med, Dept Crit Care Med 2, GR-10679 Athens, Greece
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Theodorakopoulou, M.
;
Karagianni, V.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Karagianni, V.
;
Douzinas, E.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Athens, Sch Med, Dept Crit Care Med 3, GR-10679 Athens, Greece
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Douzinas, E.
;
Armaganidis, A.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Athens, Sch Med, Dept Crit Care Med 2, GR-10679 Athens, Greece
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Armaganidis, A.
;
Giamarellos-Bourboulis, E. J.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Univ Athens, Sch Med, Dept Internal Med 4, GR-10679 Athens, Greece
Giamarellos-Bourboulis, E. J.
.
INFLAMMATION RESEARCH,
2009,
58
(03)
:127
-132
[3]
Prognostic value of plasma N-terminal pro-brain natriuretic peptide in patients with severe sepsis
[J].
Brueckmann, M
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Heidelberg, Dept Med 1, Fac Clin Med Mannheim, D-68167 Mannheim, Germany
Brueckmann, M
;
Huhle, G
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Heidelberg, Dept Med 1, Fac Clin Med Mannheim, D-68167 Mannheim, Germany
Huhle, G
;
Lang, S
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Heidelberg, Dept Med 1, Fac Clin Med Mannheim, D-68167 Mannheim, Germany
Lang, S
;
Haase, KK
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Heidelberg, Dept Med 1, Fac Clin Med Mannheim, D-68167 Mannheim, Germany
Haase, KK
;
Bertsch, T
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Heidelberg, Dept Med 1, Fac Clin Med Mannheim, D-68167 Mannheim, Germany
Bertsch, T
;
Weiss, C
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Heidelberg, Dept Med 1, Fac Clin Med Mannheim, D-68167 Mannheim, Germany
Weiss, C
;
Kaden, JJ
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Heidelberg, Dept Med 1, Fac Clin Med Mannheim, D-68167 Mannheim, Germany
Kaden, JJ
;
Putensen, C
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Heidelberg, Dept Med 1, Fac Clin Med Mannheim, D-68167 Mannheim, Germany
Putensen, C
;
Borggrefe, M
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Heidelberg, Dept Med 1, Fac Clin Med Mannheim, D-68167 Mannheim, Germany
Borggrefe, M
;
Hoffmann, U
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Heidelberg, Dept Med 1, Fac Clin Med Mannheim, D-68167 Mannheim, Germany
Hoffmann, U
.
CIRCULATION,
2005,
112
(04)
:527
-534
[4]
Proteolytic processing pattern of the endothelin-1 precursor in vivo
[J].
Struck, J
论文数:
0
引用数:
0
h-index:
0
机构:
BRAHMS Aktiengesell, Res Dept, D-16761 Hennigsdorf, Germany
BRAHMS Aktiengesell, Res Dept, D-16761 Hennigsdorf, Germany
Struck, J
;
Morgenthaler, NG
论文数:
0
引用数:
0
h-index:
0
机构:
BRAHMS Aktiengesell, Res Dept, D-16761 Hennigsdorf, Germany
BRAHMS Aktiengesell, Res Dept, D-16761 Hennigsdorf, Germany
Morgenthaler, NG
;
Bergmann, A
论文数:
0
引用数:
0
h-index:
0
机构:
BRAHMS Aktiengesell, Res Dept, D-16761 Hennigsdorf, Germany
BRAHMS Aktiengesell, Res Dept, D-16761 Hennigsdorf, Germany
Bergmann, A
.
PEPTIDES,
2005,
26
(12)
:2482
-2486
[5]
Time-course of sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin, and C-reactive protein plasma concentrations during sepsis
[J].
Gibot, S
论文数:
0
引用数:
0
h-index:
0
机构:
Hop Cent, Serv Reanimat Med, Nancy, France
Hop Cent, Serv Reanimat Med, Nancy, France
Gibot, S
;
Cravoisy, A
论文数:
0
引用数:
0
h-index:
0
机构:
Hop Cent, Serv Reanimat Med, Nancy, France
Cravoisy, A
;
Kolopp-Sarda, MN
论文数:
0
引用数:
0
h-index:
0
机构:
Hop Cent, Serv Reanimat Med, Nancy, France
Kolopp-Sarda, MN
;
Béné, MC
论文数:
0
引用数:
0
h-index:
0
机构:
Hop Cent, Serv Reanimat Med, Nancy, France
Béné, MC
;
Faure, G
论文数:
0
引用数:
0
h-index:
0
机构:
Hop Cent, Serv Reanimat Med, Nancy, France
Faure, G
;
Bollaert, PE
论文数:
0
引用数:
0
h-index:
0
机构:
Hop Cent, Serv Reanimat Med, Nancy, France
Bollaert, PE
;
Levy, B
论文数:
0
引用数:
0
h-index:
0
机构:
Hop Cent, Serv Reanimat Med, Nancy, France
Levy, B
.
CRITICAL CARE MEDICINE,
2005,
33
(04)
:792
-796
[6]
Comparison of procalcitonin and C-reactive protein as markers of sepsis
[J].
Luzzani, A
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Hosp, Inst Anesthesiol & Intens Care, Verona, Italy
Univ Hosp, Inst Anesthesiol & Intens Care, Verona, Italy
Luzzani, A
;
Polati, E
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Hosp, Inst Anesthesiol & Intens Care, Verona, Italy
Polati, E
;
Dorizzi, R
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Hosp, Inst Anesthesiol & Intens Care, Verona, Italy
Dorizzi, R
;
Rungatscher, A
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Hosp, Inst Anesthesiol & Intens Care, Verona, Italy
Rungatscher, A
;
Pavan, R
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Hosp, Inst Anesthesiol & Intens Care, Verona, Italy
Pavan, R
;
Merlini, A
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Hosp, Inst Anesthesiol & Intens Care, Verona, Italy
Merlini, A
.
CRITICAL CARE MEDICINE,
2003,
31
(06)
:1737
-1741
←
1
→