Epac信号分子与哮喘关系研究进展

被引：4

作者：

黄革

高亚东

机构：

[1] 武汉大学中南医院呼吸内科

来源：

海南医学 | 2015年 / 26卷 / 12期

关键词：

支气管哮喘; 环磷酸腺苷; cAMP直接激活的交换蛋白; 蛋白激酶A;

D O I：

暂无

中图分类号：

R562.25 [];

学科分类号：

摘要：

支气管哮喘是临床常见的气道慢性炎症性疾病,以气道高反应性、慢性气道炎症和气道重塑为病理生理特征,其发病机制目前尚未完全阐明。环磷酸腺苷(c AMP)是体内重要的第二信使,参与调控机体新陈代谢、细胞钙信号传导、细胞生长与分化、凋亡等多种病理生理过程。长期以来,蛋白激酶A(PKA)被认为是介导c AMP生物学效应的唯一下游信号分子。但新近发现的新型c AMP靶分子——c AMP直接激活的交换蛋白(Epac)的发现打破了这一说法。大量研究证实,Epac可单独或协同PKA介导c AMP的多种生物学效应。本文就Epac在支气管哮喘发病中的作用及其可能机制作一综述,为寻找哮喘治疗新靶点奠定基础。

引用

页码：1791 / 1793

页数：3

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