黏蛋白在肠黏膜屏障中的保护调节机制

被引：40

作者：

贺欣

张目涵

路瑶

冯百岁

机构：

[1] 郑州大学第二附属医院消化内科

来源：

医学综述 | 2017年 / 23卷 / 01期

关键词：

肠黏膜屏障; 黏蛋白; 益生菌; O型寡糖链; 黏液;

D O I：

暂无

中图分类号：

R574 [肠疾病];

学科分类号：

100201 [内科学];

摘要：

由化学屏障、机械屏障、生物屏障和免疫屏障共同构成的肠黏膜屏障在防止细菌和抗原等有害物质入侵以及维持肠道营养吸收等过程中起重要作用。而同样具有多种类型的黏蛋白是一类广泛存在于各个组织和器官中的高相对分子质量、高度糖基化修饰的蛋白家族。了解黏蛋白与肠黏膜屏障的关系,将有助于了解肠道内复杂详尽的病理生理学机制,为肠黏膜相关疾病的治疗寻找新的思路和方法。

引用

收藏

页码：1 / 5

页数：5

相关论文

共 20 条

[1]

Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer [J].

Landy, Jonathan ;

Ronde, Emma ;

English, Nick ;

Clark, Sue K. ;

Hart, Ailsa L. ;

Knight, Stella C. ;

Ciclitira, Paul J. ;

Al-Hassi, Hafid Omar .

WORLD JOURNAL OF GASTROENTEROLOGY, 2016, 22 (11) :3117-3126

[2]

Bacterial colonization and intestinal mucosal barrier development.[J].Xiao-Zhong Huang;Li-Bin Zhu;Zhong-Rong Li;Jing Lin;.World Journal of Clinical Pediatrics.2013, 04

[3]

The colonic mucus protection depends on the microbiota [J].

Rodriguez-Pineiro, Ana M. ;

Johansson, Malin E., V .

GUT MICROBES, 2015, 6 (05) :326-330

[4]

Structural insights into bacterial recognition of intestinal mucins.[J].Sabrina Etzold;Nathalie Juge.Current Opinion in Structural Biology.2014,

[5]

The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system [J].

Pelaseyed, Thaher ;

Bergstrom, Joakim H. ;

Gustafsson, Jenny K. ;

Ermund, Anna ;

Birchenough, George M. H. ;

Schutte, Andre ;

van der Post, Sjoerd ;

Svensson, Frida ;

Rodriguez-Pineiro, Ana M. ;

Nystrom, Elisabeth E. L. ;

Wising, Catharina ;

Johansson, Malin E. V. ;

Hansson, Gunnar C. .

IMMUNOLOGICAL REVIEWS, 2014, 260 (01) :8-20

[6]

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion [J].

Wlodarska, Marta ;

Thaiss, Christoph A. ;

Nowarski, Roni ;

Henao-Mejia, Jorge ;

Zhang, Jian-Ping ;

Brown, Eric M. ;

Frankel, Gad ;

Levy, Maayan ;

Katz, Meirav N. ;

Philbrick, William M. ;

Elinav, Eran ;

Finlay, B. Brett ;

Flavell, Richard A. .

CELL, 2014, 156 (05) :1045-1059

[7]

Mucins: A biologically relevant glycan barrier in mucosal protection [J].

Corfield, Anthony P. .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2015, 1850 (01) :236-252

[8]

Molecular dialogue between the human gut microbiota and the host: a Lactobacillus and Bifidobacterium perspective [J].

Turroni, Francesca ;

Ventura, Marco ;

Butto, Ludovica F. ;

Duranti, Sabrina ;

O'Toole, Paul W. ;

Motherway, Mary O'Connell ;

van Sinderen, Douwe .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2014, 71 (02) :183-203

[9]

Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals [J].

Shan, Meimei ;

Gentile, Maurizio ;

Yeiser, John R. ;

Walland, A. Cooper ;

Bornstein, Victor U. ;

Chen, Kang ;

He, Bing ;

Cassis, Linda ;

Bigas, Anna ;

Cols, Montserrat ;

Comerma, Laura ;

Huang, Bihui ;

Blander, J. Magarian ;

Xiong, Huabao ;

Mayer, Lloyd ;

Berin, Cecilia ;

Augenlicht, Leonard H. ;

Velcich, Anna ;

Cerutti, Andrea .

SCIENCE, 2013, 342 (6157) :447-453

[10]

Mucus Coat, a Dress Code for Tolerance [J].

Belkaid, Yasmine ;

Grainger, John .

SCIENCE, 2013, 342 (6157) :432-433