血小板ADP受体及其拮抗剂的研究进展

被引：14

作者：

庄旭琴 ^{[1
]}

霍建丽 ^{[2
]}

杨天雨 ^{[2
]}

孔毅 ^{[2
]}

机构：

[1] 江苏省淮安市第一人民医院

[2] 中国药科大学生命科学与技术学院

来源：

药物生物技术 | 2010年 / 17卷 / 03期

关键词：

抗血小板; P2Y1受体; P2Y12受体; P2X1受体; 拮抗剂;

D O I：

10.19526/j.cnki.1005-8915.2010.03.022

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

ADP是人们发现最早也是体内最重要的诱导血小板聚集的物质,其在止血块和病理性动脉血栓形成中起到关键的作用。ADP对血小板的作用主要是通过与血小板膜ADP受体结合后导致血小板形态变化或使cAMP水平降低而聚集,但与凝血酶或胶原相比,其本身是一种弱的血小板激活剂,另因为ADP可以增强或放大其他激活剂的作用,而被认为是血小板激活必需的共同因子。ADP受体拮抗剂可以抑制ADP受体的表达、结合及其活性,从而有效地抑制了血小板的聚集,对血栓性疾病的治疗具有重要的作用。目前,ADP受体拮抗剂类药物因为具有较好的抗栓活性和较高的安全性,已经被较广泛的应用于临床。本文对血小板ADP受体的类型及重要的受体拮抗剂进行了综述,对该类药物的研究开发具有一定的参考价值。

引用

页码：278 / 282

页数：5

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