Cajal间质细胞在胆囊结石形成中的作用分析

被引：10

作者：

彭雅亚 ^{[1
]}

谭宇彦 ^{[2
]}

机构：

[1] 湘潭市第二人民医病理科

[2] 东南大学附属中大医院

来源：

标记免疫分析与临床 | 2016年 / 23卷 / 07期

关键词：

胆囊结石; Cajal间质细胞; c-kit;

D O I：

暂无

中图分类号：

R575.6 [胆囊疾病];

学科分类号：

100201 [内科学];

摘要：

目的观察Cajal间质细胞(interstitial cell of Cajal,ICC)和c-kit蛋白在正常胆囊和结石胆囊中的分布和表达情况,探讨ICC与胆囊结石发病的关系。方法对手术切除的25例结石胆囊和15例非结石胆囊石蜡包埋组织标本和新鲜组织,通过c-kit免疫组化染色和Western blot,对两组胆囊标本ICC和c-kit蛋白进行检测。结果所有胆囊标本中均发现c-kit阳性的ICC分布于胆囊平滑肌层,结石胆囊ICC数目和c-kit蛋白表达明显少于非结石胆囊。结论胆囊结石发病过程中胆囊动力学的减弱有可能与ICC的减少有一定关联。

引用

页码：817 / 819

页数：3

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