缺血性脑损伤后神经元凋亡相关基因表达的研究进展

被引：2

作者：

周瑞祥

机构：

[1] 华中科技大学同济医学院附属协和医院神经科()

来源：

国外医学神经病学神经外科学分册. | 2002年 / 02期

关键词：

脑缺血; 凋亡; 基因表达;

D O I：

10.16636/j.cnki.jinn.2002.02.004

中图分类号：

R743 [脑血管疾病];

学科分类号：

摘要：

神经元凋亡是缺血性脑损伤后细胞死亡的一种重要形式，脑缺血后许多基因被诱导表达并且作为调控因子参与了神经元凋亡过程，主要包括Ｂｃｌ－２、Ｈｓｐ７０、ｐ５３、ｃ－ｆｏｓ等基因，本文综述了这些凋亡相关基因和蛋白质产物在缺血性脑损伤后的表达及发挥的作用。

引用

页码：106 / 109

页数：4

共 16 条

[11]

Ischemia-induced interleukin-6 as a potential endogenous neuroprotective cytokine against NMDA receptor-mediated excitotoxicity in the brain. Ali C,Nicole O,Docagne F,et al. Journal of Cerebral Blood Flow and Metabolism . 2000

[12]

Simultaneous induction of mitochondrial heat shock protein mRNAs in rat forebrain ischemia. Okubo A,Kinouchi H,Owada Y,et al. Brain Research Molecular Brain Research . 2000

[13]

Dynamics of regional brain metabolism and gene expression after middle cerebral artery occlusion in mice. Hata R,Maeda K,Hermann D,et al. Journal of Cerebral Blood Flow and Metabolism . 2000

[14]

Expression of c-jun,hsp72 and gfap following repeated unilateral common carotid artery occlusion in gerbils-correlates of delayed ischemic injury. Ermann DM,Kuroiwa T,Ito U,et al. Brain Research . 1998

[15]

Apoptotic DNA fragmentation and upregulation of Bax induced by transient ischemia of the rat retina. Aneda K,Kashii S,Kurosawa T,et al. Brain Research . 1999

[16]

Caspase mRNA expression in a rat model of focal cerebral ischemia. Harrison DC,Davis RP,Bond BC,et al. Brain Research Molecular Brain Research . 2001

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