遗传基因与帕金森病相关性的研究进展

被引：6

作者：

封华

刘承伟

机构：

[1] 桂林医学院解剖学教研室

来源：

中国老年学杂志 | 2011年 / 31卷 / 10期

关键词：

帕金森病; 发病机制; 遗传基因; 研究进展;

D O I：

暂无

中图分类号：

R742.5 [震颤麻痹综合征];

学科分类号：

100204 [神经病学];

摘要：

<正>帕金森病(PD)已成为人们普遍关注的社会问题,也是当今社会及未来要挑战的公共卫生事业。尽管进行了有关环境毒素和基因突变等复杂证据的相关研究,但PD的病因一直没有得到准确的解释。回顾近年来PD发病机制的研究进展,在

引用

收藏

页码：1911 / 1913

页数：3

相关论文

共 11 条

[1]

Parkin基因多态性与帕金森病遗传易患性关系的研究 [J].

洪雁 ;

张本恕 .

中国现代神经疾病杂志, 2006, (04) :291-294

[2]

The regulatory role of α-synuclein and parkin in neuronal cell apoptosis; possible implications for the pathogenesis of Parkinson's disease [J].

Yasuda, Toru ;

Mochizuki, Hideki .

APOPTOSIS, 2010, 15 (11) :1312-1321

[3]

Deciphering the role of heterozygous mutations in genes associated with parkinsonism [J].

Klein, Christine ;

Lohmann-Hedrich, Katja ;

Rogaeva, Ekaterina ;

Schlossmacher, Michael G. ;

Lang, Anthony E. .

LANCET NEUROLOGY, 2007, 6 (07) :652-662

[4]

Evaluation of LRRK2 G2019S penetrance -: Relevance for genetic counseling in Parkinson disease [J].

Goldwurm, S. ;

Zini, M. ;

Mariani, L. ;

Tesei, S. ;

Miceli, R. ;

Sironi, F. ;

Clementi, M. ;

Bonifati, V. ;

Pezzoli, G. .

NEUROLOGY, 2007, 68 (14) :1141-1143

[5]

A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson's disease risk in Taiwan [J].

Di Fonzo, Alessio ;

Wu-Chou, Yah-Huei ;

Lu, Chin-Song ;

van Doeselaar, Marina ;

Simons, Erik J. ;

Rohe, Christan F. ;

Chang, Hsiu-Chen ;

Chen, Rou-Shayn ;

Weng, Yi-Hsin ;

Vanacore, Nicola ;

Breedveld, Guido J. ;

Oostra, Ben A. ;

Bonifati, Vincenzo .

NEUROGENETICS, 2006, 7 (03) :133-138

[6]

Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y [J].

Deng, H ;

Jankovic, J ;

Guo, Y ;

Xie, WJ ;

Le, WD .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 337 (04) :1133-1138

[7]

Clinicogenetic study of PINK1 mutations in autosomal recessive early-onset parkinsonism [J].

Li, Y ;

Tomiyama, H ;

Sato, K ;

Hatano, Y ;

Yoshino, H ;

Atsumi, M ;

Kitaguchi, M ;

Sasaki, S ;

Kawaguchi, S ;

Miyajima, H ;

Toda, T ;

Mizuno, Y ;

Hattori, N .

NEUROLOGY, 2005, 64 (11) :1955-1957

[8]

DJ-1 (PARK7), a novel gene for autosomal recessive, early onset parkinsonism [J].

Bonifati, V ;

Rizzu, P ;

Squitieri, F ;

Krieger, E ;

Vanacore, N ;

van Swieten, JC ;

Brice, A ;

van Duijn, CM ;

Oostra, B ;

Meco, G ;

Heutink, P .

NEUROLOGICAL SCIENCES, 2003, 24 (03) :159-160

[9]

Polymorphism in the human DJ-1 gene is not associated with sporadic dementia with Lewy bodies or Parkinson's disease [J].

Morris, CM ;

O'Brien, KK ;

Gibson, AM ;

Hardy, JA ;

Singleton, AB .

NEUROSCIENCE LETTERS, 2003, 352 (02) :151-153

[10]

Parkin mutations and susceptibility alleles in late-onset Parkinson's disease [J].

Oliveira, SA ;

Scott, WK ;

Martin, ER ;

Nance, MA ;

Watts, RL ;

Hubble, JP ;

Koller, WC ;

Pahwa, R ;

Stern, MB ;

Hiner, BC ;

Ondo, WG ;

Allen, FH ;

Scott, BL ;

Goetz, CG ;

Small, GW ;

Mastaglia, F ;

Stajich, JM ;

Zhang, FY ;

Booze, MW ;

Winn, MP ;

Middleton, LT ;

Haines, JL ;

Pericak-Vance, MA ;

Vance, JM .

ANNALS OF NEUROLOGY, 2003, 53 (05) :624-629