青蒿素类化合物抗肿瘤研究进展

被引：32

作者：

陆金健

机构：

[1] 浙江中医药大学生命科学学院

来源：

中国药理学通报 | 2010年 / 06期

关键词：

青蒿素; 氧化应激; 周期阻滞; 细胞凋亡; 抗血管新生; 抗肿瘤;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理]; R73-36 [治疗实验];

学科分类号：

100214 [肿瘤学]; 100806 [中药药理学];

摘要：

青蒿素类化合物是一类有效的抗疟疾药物,近年来研究显示该类化合物也具有良好的抗肿瘤作用。其抗肿瘤机制主要包括铁参与的氧化应激反应、阻滞细胞周期、诱导细胞凋亡以及抗新生血管生成等。由于青蒿素类化合物对正常组织细胞毒性小,且对多药耐药的肿瘤细胞仍然有效,因此,开发该类化合物作为新型的抗肿瘤药物具有广阔前景。

引用

页码：818 / 820

页数：3

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