芍药甘草汤镇痛作用研究及镇痛效果与配伍比例相关性分析(英文)

被引:21
作者
汪萌
闫永红
邹慧琴
朱广伟
彭莲
李佳慧
机构
[1] 北京中医药大学
关键词
芍药甘草汤; 药效组分; 镇痛作用; 配伍比例;
D O I
暂无
中图分类号
R285.5 [中药实验药理];
学科分类号
100806 [中药药理学];
摘要
目的:将白芍的4种药效组分、甘草的5种药效组分根据芍药甘草汤中的药效组分实测值进行配伍,配伍成芍药甘草汤组分中药研究镇痛作用。方法:分别将昆明种小鼠随机分为空白组、阳性对照组(阿司匹林10mg/kg)、芍药甘草汤组(10,20,30mg/kg),口服给药观察芍药甘草汤的镇痛效果。结果:芍药甘草汤组分中药显示出显著的镇痛效果,药效组分配伍比例相同时镇痛效果相似,药效组分配伍比例不同时镇痛效果有显著差异。结论:药效组分配伍比例相同时代表相同的组分中药,因此具有相同的治疗作用;药效组分配伍比例不同时候,代表不同的组分中药,因此具有不同的治疗作用。
引用
收藏
页码:1767 / 1773
页数:7
相关论文
共 11 条
[1]
Pharmacokinetic Comparisons of Albiflorin and Paeoniflorin after Oral Administration of Shaoyao-Gancao-Tang and Single Herb Paeony Decoction to Rats [J].
Gan, Pingping ;
Zhong, Meizuo ;
Huang, Xi ;
Sun, Ming ;
Wang, Yang ;
Xiao, Yanying ;
Zeng, Chang ;
Yuan, Qiongjing ;
Liu, Zhaoqian ;
Zhou, Honghao .
PLANTA MEDICA, 2012, 78 (03) :237-243
[2]
Effects of total glucosides of paeony on oxidative stress in the kidney from diabetic rats.[J].Jing Su;Pei Zhang;Jing-Jing Zhang;Xiang-Ming Qi;Yong-Gui Wu;Ji-Jia Shen.Phytomedicine.2009, 3
[3]
Analgesic and anti-inflammatory activities of a water extract of Trachelospermum jasminoides (Apocynaceae) [J].
Sheu, Ming-Jyh ;
Chou, Pei-Yu ;
Cheng, Hsu-Chen ;
Wu, Chieh-Hsi ;
Huang, Guan-Jhong ;
Wang, Bor-Sen ;
Chen, Jwo-Sheng ;
Chien, Yi-Chung ;
Huang, Ming-Hsing .
JOURNAL OF ETHNOPHARMACOLOGY, 2009, 126 (02) :332-338
[4]
Chemical analysis of the Chinese herbal medicine Gan-Cao (licorice).[J].Qingying Zhang;Min Ye.Journal of Chromatography A.2008, 11
[5]
Isoliquiritigenin; a flavonoid from licorice; relaxes guinea-pig tracheal smooth muscle in vitro and in vivo : Role of cGMP/PKG pathway.[J].Bin Liu;Jing Yang;Qingshan Wen;Ying Li.European Journal of Pharmacology.2008, 1
[6]
The determination of glycyrrhizic acid in Glycyrrhiza uralensis Fisch. ex DC. (Zhi Gan Cao) root and the dried aqueous extract by LC–DAD.[J].J.R. Hennell;S. Lee;C.S. Khoo;M.J. Gray;A. Bensoussan.Journal of Pharmaceutical and Biomedical Analysis.2008, 3
[7]
Antinociceptive effects of systemic paeoniflorin on bee venom-induced various ‘phenotypes’ of nociception and hypersensitivity.[J].Hou-You Yu;Ming-Gang Liu;Dan-Na Liu;Gang-Wei Shang;Yan Wang;Chao Qi;Kui-Ping Zhang;Zu-Jun Song;Jun Chen.Pharmacology; Biochemistry and Behavior.2007, 2
[8]
Orthogonal array design for optimizing extraction efficiency of active constituents from Jakyak-Gamcho Decoction, the complex formula of herbal medicines, Paeoniae Radix and Glycyrrhizae Radix [J].
Guo, Lianyu ;
Cho, So Yean ;
Kang, Sam Sik ;
Lee, Seung-Ho ;
Baek, Hum-Young ;
Kim, Yeong Shik .
JOURNAL OF ETHNOPHARMACOLOGY, 2007, 113 (02) :306-311
[9]
Separation of glycyrrhizic acid and liquiritin from Glycyrrhiza uralensis Fisch extract by three-liquid-phase extraction systems.[J].Shufeng Shen;Zhidong Chang;Ji Liu;Xinghua Sun;Xin Hu;Huizhou Liu.Separation and Purification Technology.2006, 3
[10]
Paeoniflorin attenuates chronic cerebral hypoperfusion-induced learning dysfunction and brain damage in rats.[J].Jing Liu;Dao-Zhong Jin;Liang Xiao;Xing-Zu Zhu.Brain Research.2006, 1