CEA多肽负载的自体树突状细胞治疗晚期肺癌8例近期疗效观察

被引:2
作者
文洽先 [1 ]
朱娅 [1 ]
许彬 [1 ]
项方 [2 ]
李丽 [2 ]
机构
[1] 无锡市第三人民医院肿瘤血液科
[2] 南京得康生物技术有限公司
关键词
进展期肺癌; 树突状细胞; 免疫治疗;
D O I
暂无
中图分类号
R734.2 [肺肿瘤];
学科分类号
100214 ;
摘要
目的探讨CEA多肽负载的自体树突状细胞(DC)治疗晚期肺癌的安全性和近期疗效。方法分离患者外周血单核细胞,用重组人粒细胞-巨噬细胞集落刺激因子(rhGM-CSF)和白介素-4(rhIL-4)体外诱导DC,CEA多肽负载自体DC,对8例HLA-A2阳性且CEA较高的晚期肺癌患者进行4次DC免疫治疗,观察其安全性、免疫功能和临床疗效。结果治疗中未出现明显不良反应,血清中IL-2、IL-12、IFN-γ和TNF-α水平治疗后呈明显上升趋势,4例患者的DTH检测阳性;4例患者血清CEA降低,2例平稳,2例升高。7例有可评价病灶的患者中,1例部分缓解(PR)、1例轻微缓解(MR)、3例稳定(SD)、2例进展(PD)。结论CEA负载的自体DC治疗晚期肺癌患者可改善患者的免疫功能,激发特异性免疫反应,缓解病情,且不良反应少,为肺癌的免疫治疗提供了一条新途径。
引用
收藏
页码:168 / 170+224 +224
页数:4
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