Dendritic cells dysfunction in tumour environment

被引：54

作者：

Bennaceur, Karim ^{[1
,2
]}

Chapman, Jessica ^{[4
]}

Brikci-Nigassa, Leila ^{[1
,2
]}

Sanhadji, Kamel ^{[1
,2
]}

Touraine, Jean-Louis ^{[1
,2
]}

Portoukalian, Jacques ^{[3
]}

机构：

[1] Univ Lyon 1, Dept Transplantat & Clin Immunol, Lyon, France

[2] Hop Edouard Herriot, Lyon, France

[3] Univ Lyon 1, Lab Dermatol Res, Dept R, Hop Edouard Herriot,EA 41 69, F-69437 Lyon 03, France

[4] Univ Manchester, Fac Life Sci, Manchester M13 9PL, Lancs, England

来源：

CANCER LETTERS | 2008年 / 272卷 / 02期

关键词：

Tumour escape; Dendritic cells; Immune dysfunction; Tumour microenvironment;

D O I：

10.1016/j.canlet.2008.05.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Several studies indicate that most tumours are immunogenic and they rarely succeed to induce an efficient immune response. Many mechanisms have been involved in the tumour escape from host immune surveillance. The tumour microenvironment has emerged as an important component contributing to dendritic cells (DCs) dysfunction. There is evidence that DCs play a key role in the induction of tumour-specific immune responses, especially via cross-priming through MHC-class I antigens presentation. In this review we will discuss the potential role of the tumour microenvironment in DCs dysfunction. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：186 / 196

页数：11

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