Induction of dendritic cell differentiation by IFN-α in systemic lupus erythematosus

被引：1012

作者：

Blanco, P

Palucka, AK

Gill, M

Pascual, V

Banchereau, J ^{[1
]}

机构：

[1] Baylor Inst Immunol Res, Dallas, TX 75204 USA

[2] Univ Texas, SW Med Ctr, Dallas, TX 75390 USA

来源：

SCIENCE | 2001年 / 294卷 / 5546期

关键词：

D O I：

10.1126/science.1064890

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Dendritic cells (DCs) are important in regulating both immunity and tolerance. Hence, we hypothesized that systemic lupus erythematosus (SLE), an autoimmune disease characterized by autoreactive B and T cells, may be caused by alterations in the functions of DCs. Consistent with this, monocytes from SLE patients' blood were found to function as antigen-presenting cells, in vitro. Furthermore, serum from SLE patients induced normal monocytes to differentiate into DCs. These DCs could capture antigens from dying cells and present them to CD4-positive T cells. The capacity of SLE patients' serum to induce DC differentiation correlated with disease activity and depended on the actions of interferon-alpha (IFN-alpha). Thus, unabated induction of DCs by IFN-alpha may drive the autoimmune response in SLE.

引用

页码：1540 / 1543

页数：4

共 27 条

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