DOR-β-arrestin1-Bcl-2/NF-κB信号转导通路在溃疡性结肠炎发病机制中的研究

被引：17

作者：

陈小艳

范恒

张丽娟

刘星星

钟敏

机构：

[1] 华中科技大学同济医学院附属协和医院中西医结合科

来源：

中西医结合研究 | 2011年 / 3卷 / 04期

关键词：

D O I：

暂无

中图分类号：

R574.62 [结肠疾病];

学科分类号：

100201 [内科学];

摘要：

<正>溃疡性结肠炎(ulcerative colitis,UC)是慢性非特异性肠道炎性疾病,其在临床上有长期性、慢性、难治性和易复发的特点。肠道微环境改变后,易感人群肠

引用

收藏

页码：197 / 202

页数：6

相关论文

共 9 条

[1]

A novel gene P28GANK confers multidrug resistance by modulating the expression of MDR-1, Bcl-2, and bax in osteosarcoma cells [J].

Wang, Guowen ;

Rong, Jiesheng ;

Zhou, Zhihong ;

Duo, Jian .

MOLECULAR BIOLOGY, 2010, 44 (06) :898-906

[2]

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer [J].

Grivennikov, Sergei ;

Karin, Eliad ;

Terzic, Janos ;

Mucida, Daniel ;

Yu, Guann-Yi ;

Vallabhapurapu, Sivakumar ;

Scheller, Juergen ;

Rose-John, Stefan ;

Cheroutre, Hilde ;

Eckmann, Lars ;

Karin, Michael .

CANCER CELL, 2009, 15 (02) :103-113

[3]

Blocking them all:: β-arrestins inhibit cellular signaling [J].

Lohse, Martin J. ;

Klenk, Christoph .

MOLECULAR CELL, 2008, 31 (05) :619-621

[4]

Nuclear β-arrestin1 functions as a scaffold for the dephosphorylation of STAT1 and moderates the antiviral activity of IFN-γ [J].

Mo, Wei ;

Zhang, Liang ;

Yang, Guohua ;

Zhai, Jianwei ;

Hu, Zhonghua ;

Chen, Yuelei ;

Chen, Xu ;

Hui, Lijian ;

Huang, Ruimin ;

Hu, Gengxi .

MOLECULAR CELL, 2008, 31 (05) :695-707

[5]

Shared principles in NF-κB signaling [J].

Hayden, Matthew S. ;

Ghosh, Sankar .

CELL, 2008, 132 (03) :344-362

[6]

Ribosomal protein S3:: A KH domain subunit in NF-κB complexes that mediates selective gene regulation [J].

Wan, Fengyi ;

Anderson, D. Eric ;

Barnitz, Robert A. ;

Snow, Andrew ;

Bidere, Nicolas ;

Zheng, Lixin ;

Hegde, Vijay ;

Lam, Lloyd T. ;

Staudt, Louis M. ;

Levens, David ;

Deutsch, Walter A. ;

Lenardo, Michael J. .

CELL, 2007, 131 (05) :927-939

[7]

A nuclear function of β-arrestin1 in GPCR signaling:: Regulation of histone acetylation and gene transcription [J].

Kang, JH ;

Shi, YF ;

Xiang, B ;

Qu, B ;

Su, WJ ;

Zhu, M ;

Zhang, M ;

Bao, GB ;

Wang, FF ;

Zhang, XQ ;

Yang, RX ;

Fan, FJ ;

Chen, XQ ;

Pei, G ;

Ma, L .

CELL, 2005, 123 (05) :833-847

[8]

β-arrestin1在实验性大鼠结肠炎发生机制中的作用及氧化苦参碱的干预作用.[J].廖奕;范恒;陈小艳;张丽娟;.中国中西医结合杂志.2010, 10

[9]

Effect of probiotics on pro-inflammatory cytokines and NF-κB activation in ulcerative colitis [J].

Hegazy, Sahar K. ;

El-Bedewy, Mohamed M. .

WORLD JOURNAL OF GASTROENTEROLOGY, 2010, 16 (33) :4145-4151