2型糖尿病并发心肌梗死患者血清脑钠肽N末端前体水平检测

被引：4

作者：

李媛媛 ^{[1
]}

王芳 ^{[2
]}

机构：

[1] 开封市第二人民医院检验科

[2] 河南大学第一附属医院检验科

来源：

郑州大学学报(医学版) | 2008年 / 04期

关键词：

2型糖尿病; 心肌梗死; 脑钠肽N末端前体;

D O I：

10.13705/j.issn.1671-6825.2008.04.032

中图分类号：

R587.1 [糖尿病]; R542.22 [];

学科分类号：

摘要：

目的:探讨2型糖尿病并发心肌梗死(T2DM-MI)与血清脑钠肽N末端前体(NT-proBNP)的关系。方法:采用酶联免疫吸附方法检测60例T2DM、70例T2DM-MI患者及80例健康人(对照组)血清中NT-proBNP水平,同时测定CK和CK-MB水平,记录峰值浓度,并分析T2DM-MI组血清NT-proBNP水平与CK、CK-MB之间的相关性。结果:T2DM-MI组和T2DM组血清NT-proBNP、CK及CK-MB水平高于对照组(P<0.05),T2DM-MI组高于T2DM组(P<0.05)。T2DM-MI组血清NT-proBNP水平与CK、CK-MB峰值浓度呈正相关(r分别为0.820,0.811,P均<0.05)。结论:血清NT-proBNP水平有望成为T2DM并发MI的重要标志物。

引用

页码：754 / 756

页数：3

共 7 条

[1] 心绞痛患者血浆N-proBNP水平的变化及其临床意义 [J].

刘梅林 ;

李继敏 ;

胡大一 ;

马志敏 ;

高霖 ;

庞永正 .

中华心血管病杂志, 2004, (06) :20-23

[2]

N-terminal pro-brain natriuretic peptide (NT-proBNP) in Type 2 diabetes with left ventricular dysfunction[J] . Ji-Youn Kim,Eun Young Lee,Jae-Hwan Jee,Byung-Wan Lee,Jae Hoon Chung,Eun Suk Jeun,Yong-Ki Min,Myung-Shik Lee,Kwang-Won Kim,Moon-Kyu Lee.Diabetes Research and Clinical Practice . 2007 (3)

[3]

Relationship between slightly elevated NT-proBNP and alterations in diastolic function detected by echocardiography in patients without structural heart disease[J] . Antonio Barragán,Juan Lacalzada,Alejandro de la Rosa,Antonia María de Vera,Amelia Duque,César Perera,Antonio Lara,Ignacio Laynez.International Journal of Cardiology . 2007 (3)

[4]

N-Terminal Pro-Brain Natriuretic Peptide on Admission in Patients With Acute Myocardial Infarction and Correlation With Scintigraphic Infarct Size, Efficacy of Reperfusion, and Prognosis[J] . The American Journal of Cardiology . 2006 (8)

[5]

N-Terminal Pro–B-Type Natriuretic Peptide and Matrix Metalloproteinases in Early and Late Left Ventricular Remodeling After Acute Myocardial Infarction[J] . Dimitrios N. Tziakas,Georgios K. Chalikias,Eleni I. Hatzinikolaou,Dimitrios A. Stakos,Ioannis K. Tentes,Alexandros Kortsaris,Dimitrios I. Hatseras,Juan Carlos Kaski.The American Journal of Cardiology . 2005 (1)

[6]

N-Terminal Pro-Brain Natriuretic Peptide and Other Risk Markers for the Separate Prediction of Mortality and Subsequent Myocardial Infarction in Patients With Unstable Coronary Artery Disease: A Global Utilization of Strategies To Open occluded arteries (GUSTO)-IV Substudy[J] . Stefan K James,Bertil Lindahl,Agneta Siegbahn,Mats Stridsberg,Per Venge,Paul Armstrong,Elliot S Barnathan,Robert Califf,Eric J Topol,Maarten L Simoons,Lars Wallentin.Circulation . 2003 (3)

[7]

Evaluation of B-type natriuretic peptide for risk assessment in unstable Angina/Non–ST-elevation myocardial infarction[J] . David A. Morrow,James A. de Lemos,Marc S. Sabatine,Sabina A. Murphy,Laura A. Demopoulos,Peter M. DiBattiste,Carolyn H. McCabe,C.Michael Gibson,Christopher P. Cannon,Eugene Braunwald.Journal of the American College of Cardiology . 2003 (8)

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