基础和应用基础研究是创新药物研究与开发的源泉

From the soon to be completed Human Genome Project to Combinatorial Chemistry and High Throughput Screening combined with bioinformatic tools, scientific advances are poised to revolutionize drug discovery and even health care. The research directions in the State Key Laboratory of Natural and Biomimetic Drugs of Peking University mainly focus on the study of interaction between biological targets and active compounds with structural diversity including endogenous and exogenous substances, especially the natural products that come from animals, plants and inorganic medicines. The new lead compounds have been designed and synthesized based on the structure activity relationship and computer modeling. The research activities are involved in 76 national research projects. From 1996 2000, 310 papers have been published, 8 patents obtained and 14 prizes of scientific achievements awarded by the Chinese government and ministries.