Analysis of MIF,FCGR2A and FCGR3A gene polymorphisms with susceptibility to pulmonary tuberculosis in Moroccan population

被引：4

作者：

Khalid Sadki ^{[1
]}

Hoda Lamsyah ^{[1
,2
]}

Blanca Rueda ^{[3
]}

ELmahfoud Akil ^{[4
]}

Abderrahim Sadak ^{[2
]}

Javier Martin ^{[3
]}

Rajae El Aouad ^{[5
]}

机构：

[1] Human Genomic Unit,Laboratory of Immunology,National Institute of Hygiene

[2] Department of Biology,Faculty of Sciences,University Mohammed V-Rabat Agdal 10000

[3] Department of Immunology,Instituto de Parasitología y Biomedicina López-Neyra,CSIC 4. National Reference Laboratory of Tuberculosis,National Institute of Hygiene

来源：

遗传学报 | 2010年 / 37卷 / 04期

关键词：

FCGR; MIF; polymorphism; susceptibility; pulmonary tuberculosis; Moroccan;

D O I：

暂无

中图分类号：

R521 [肺结核];

学科分类号：

1002 ; 100201 ;

摘要：

In order to investigate the influence of functional polymorphisms of macrophage migration inhibitory factor(MIF),Fcg receptors CD16A(FCGR3A) and CD32A(FCGR2A) genes on susceptibility to pulmonary tuberculosis(PTB) in the Moroccan population,we analyzed 123 patients with PTB and 154 healthy controls.The genotyping for MIF-173(G/C)(rs755622),FCGR2A-131H/R(rs1801274) and FCGR3A-158V/F(rs396991) was carried out using TaqMan SNP Genotyping Assay method.We found a statistically significant increase of the MIF-173CC homozygote genotype and MIF-173C allele frequencies in PTB patients compared with healthy controls(17.07% versus 5.84%,P=0.003;and 35.37% versus 26.30%,P=0.02;respectively).In contrast,no association was observed between FCGR2A-131H/R and FCGR3A-158V/F polymorphisms and tuberculosis disease.Our finding suggests that MIF-173C variant may play an important role in the development of active tuberculosis.

引用

页码：257 / 264

页数：8

共 16 条

[1]

Macrophage migration inhibitory factor gene: Influence on rheumatoid arthritis susceptibility[J] . Alfonso Martínez,Gisela Orozco,Jezabel Varadé,Marta Sánchez López,Dora Pascual,Alejandro Balsa,Antonio García,Emilio G. de la Concha,Benjamín Fernández-Gutiérrez,Javier Martín,Elena Urcelay.Human Immunology . 2007 (9)

[2] Macrophage migration inhibitory factor gene influences the risk of developing tuberculosis in northwestern Colombian population [J].

Gomez, L. M. ;

Sanchez, E. ;

Ruiz-Narvaez, E. A. ;

Lopez-Nevot, M. A. ;

Anaya, J.-M. ;

Martin, J. .

TISSUE ANTIGENS, 2007, 70 (01) :28-33

[3]

The involvement of Fc gamma receptor gene polymorphisms in Kawasaki disease[J] . M.Biezeveld,J.Geissler,M.Merkus,I. M.Kuipers,J.Ottenkamp,T.Kuijpers.Clinical ＆ Experimental Immunology . 2006 (1)

[4] Investigating disease susceptibility and the negative correlation of schizophrenia and rheumatoid arthritis focusing on MIF and CD14 gene polymorphisms [J].

de la Fontaine, Larissa ;

Schwarz, Markus J. ;

Riedel, Michael ;

Dehning, Sandra ;

Douhet, Anette ;

Spellmann, Ilja ;

Kleindienst, Nikolaus ;

Zill, Peter ;

Plischke, Herbert ;

Gruber, Rudolf ;

Mueller, Norbert .

PSYCHIATRY RESEARCH, 2006, 144 (01) :39-47

[5] Macrophage migration inhibitory factor and host innate immune responses to microbes [J].

Calandra, T .

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 2003, 35 (09) :573-576

[6]

Mutation screening of the macrophage migration inhibitory factor gene: Positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis[J] . RachelleDonn,ZaynabAlourfi,FabrizioDe Benedetti,CristinaMeazza,EleftheriaZeggini,MarkLunt,AdamStevens,EmmaShelley,RebeccaLamb,William E. R.Ollier,WendyThomson,DavidRay.Arthritis ＆ Rheumatism . 2002 (9)

[7] Elevated levels of serum macrophage migration inhibitory factor in patients with pulmonary tuberculosis [J].

Yamada, G ;

Shijubo, N ;

Takagi-Takahashi, Y ;

Nishihira, J ;

Mizue, Y ;

Kikuchi, K ;

Abe, S .

CLINICAL IMMUNOLOGY, 2002, 104 (02) :123-127

[8] Associations between Fc gamma receptor IIA polymorphisms and the risk and prognosis of meningococcal disease [J].

Domingo, P ;

Muñiz-Diaz, E ;

Baraldès, MA ;

Arilla, M ;

Barquet, N ;

Pericas, R ;

Juàrez, C ;

Madoz, P ;

Vázquez, G .

AMERICAN JOURNAL OF MEDICINE, 2002, 112 (01) :19-25

[9]

GENETIC DISSECTION OF IMMUNITY TO MYCOBACTERIA: The Human Model[J] . Jean-Laurent Casanova,Laurent Abel.Annual Review of Immunology . 2002

[10] Macrophage migration inhibitory factor (MIF) modulates innate immune responses induced by endotoxin and Gram-negative bacteria [J].

Roger, T ;

Glauser, MP ;

Calandra, T .

JOURNAL OF ENDOTOXIN RESEARCH, 2001, 7 (06) :456-460

← 1 2 →