脓毒症相关凝血功能障碍机制及治疗的研究进展

被引:34
作者
宋立成 [1 ]
韩志海 [2 ]
机构
[1] 解放军医学院研究生大队
[2] 中国人民解放军海军总医院呼吸内科
关键词
D O I
暂无
中图分类号
R459.7 [急症、急救处理];
学科分类号
100231 [临床病理学];
摘要
<正>脓毒症是感染导致死亡的首要因素[1]。在美国,每年新出现约100万的脓毒症病例,造成20万人死亡[2]。随着治疗手段的不断进展,重症脓毒症28 d病死率已从1991~1995年的46.9%降至2006~2009年的29%[3]。脓毒症与凝血功能异常存在不可分割的关系,最新的脓毒症诊断标准(sepsis-3):将国际标准化率(international normalized ratio,INR)>1.5或活化部分凝血活酶时间(activated partial
引用
收藏
页码:125 / 129
页数:5
相关论文
共 15 条
[1]
普通肝素对高迁移率族蛋白1介导的内皮细胞损伤的保护作用 [J].
胡博 ;
栾正刚 .
中华危重症医学杂志(电子版), 2015, 8 (04) :267-270
[2]
脓毒症相关性血小板减少症的危险因素及预后分析 [J].
孙建 ;
吴伟东 .
中华危重症医学杂志(电子版), 2014, 7 (03) :177-181
[3]
Modulation of Interleukins in Sepsis-Associated Clotting Disorders.[J].Christopher Low;Daneyal Syed;Daniel Khan;Sermin Tetik;Amanda Walborn;Debra Hoppensteadt;Michael Mosier;Jawed Fareed.Clinical and Applied Thrombosis/Hemostasis.2017, 1
[4]
Blood coagulation in immunothrombosis-At the frontline of intravascular immunity [J].
Gaertner, Florian ;
Massberg, Steffen .
SEMINARS IN IMMUNOLOGY, 2016, 28 (06) :561-569
[5]
Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense [J].
Prasad, Joni M. ;
Gorkun, Oleg V. ;
Raghu, Harini ;
Thornton, Sherry ;
Mullins, Eric S. ;
Palumbo, Joseph S. ;
Ko, Ya-Ping ;
Hoeoek, Magnus ;
David, Tovo ;
Coughlin, Shaun R. ;
Degen, Jay L. ;
Flick, Matthew J. .
BLOOD, 2015, 126 (17) :2047-2058
[6]
P-selectin promotes neutrophil extracellular trap formation in mice [J].
Etulain, Julia ;
Martinod, Kimberly ;
Wong, Siu Ling ;
Cifuni, Stephen M. ;
Schattner, Mirta ;
Wagner, Denisa D. .
BLOOD, 2015, 126 (02) :242-246
[7]
Recombinant human soluble thrombomodulin in severe sepsis: a systematic review and meta-analysis [J].
Yamakawa, K. ;
Aihara, M. ;
Ogura, H. ;
Yuhara, H. ;
Hamasaki, T. ;
Shimazu, T. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2015, 13 (04) :508-519
[8]
Heparin-Induced Thrombocytopenia in Critically Ill Patients.[J].Theodore Warkentin.Semin Thromb Hemost.2015,
[9]
Two Decades of Mortality Trends Among Patients With Severe Sepsis: A Comparative Meta-Analysis*.[J].Elizabeth K. Stevenson;Amanda R. Rubenstein;Gregory T. Radin;Renda Soylemez Wiener;Allan J. Walkey.Critical Care Medicine.2014, 3
[10]
Early intravenous unfractionated heparin and mortality in septic shock [J].
Zarychanski, Ryan ;
Doucette, Steven ;
Fergusson, Dean ;
Roberts, Daniel ;
Houston, Donald S. ;
Sharma, Satendra ;
Gulati, Harlena ;
Kumar, Anand .
CRITICAL CARE MEDICINE, 2008, 36 (11) :2973-2979