线粒体DNA异常与肿瘤

被引：1

作者：

高园

李君文

陈照立

机构：

[1] 军事医学科学院卫生学环境医学研究所

来源：

解放军预防医学杂志 | 2015年 / 33卷 / 06期

关键词：

线粒体DNA; 肿瘤; 基因突变;

D O I：

10.13704/j.cnki.jyyx.2015.06.052

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 [肿瘤学];

摘要：

线粒体功能受核DNA和线粒体DNA(mt DNA)的共同调控。mt DNA没有组蛋白保护,缺乏抗氧化机制和有效的修复系统,易发生突变或异常,导致线粒体呼吸链功能障碍,细胞出现病理性改变引发多种疾病。文章综述了mt DNA异常与肿瘤发生发展的关系,以期为寻找肿瘤早期预警的监测指标提供参考。

引用

页码：696 / 698

页数：3

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