脑出血后炎性反应机制的研究进展

被引:39
作者
胡瑞 [1 ]
张晓云 [1 ]
晏雪 [2 ]
谢凌云 [1 ]
机构
[1] 成都中医药大学
[2] 曲靖市医学高等专科学校
关键词
脑出血; 炎性反应; 综述;
D O I
暂无
中图分类号
R743.34 [脑出血];
学科分类号
1002 ;
摘要
<正>脑出血是指非外伤性脑实质内出血,在我国占卒中的17.1%55.4%[1],是临床常见的脑血管疾病,1个月内病死率>40%,多遗留严重的神经功能缺损,目前仍缺乏有效的治疗手段[2]。在脑出血患者神经损害过程中,二次损伤起着关键作用[3]。为减轻脑出血后二次损伤对患者预后的影响,其形成机制已成为研究热点。二次脑损伤的机制主要包括血-脑屏障破坏、脑水肿、炎性细胞自噬、细胞坏死及
引用
收藏
页码:370 / 374
页数:5
相关论文
共 25 条
[11]  
Role of nuclear IκB proteins in the regulation of host immune responses[J] . Masahiro Yamamoto,Kiyoshi Takeda.Journal of Infection and Chemotherapy . 2008 (4)
[12]  
Molecular inflammation: Underpinnings of aging and age-related diseases[J] . Hae Young Chung,Matteo Cesari,Stephen Anton,Emanuele Marzetti,Silvia Giovannini,Arnold Young Seo,Christy Carter,Byung Pal Yu,Christiaan Leeuwenburgh.Ageing Research Reviews . 2008 (1)
[13]   Heme oxygenase 2 deficiency increases brain swelling and inflammation after intracerebral hemorrhage [J].
Wang, J. ;
Dore, S. .
NEUROSCIENCE, 2008, 155 (04) :1133-1141
[14]   TLR2 has a detrimental role in mouse transient focal cerebral ischemia [J].
Ziegler, Gina ;
Harhausen, Denise ;
Schepers, Claudia ;
Hoffmann, Olaf ;
Roehr, Christina ;
Prinz, Vincent ;
Koenig, Janett ;
Lehrach, Hans ;
Nietfeld, Wilfried ;
Trendelenburg, George .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 359 (03) :574-579
[15]   Toll-like receptors in defense and damage of the central nervous system [J].
Aravalli, Rajagopal N. ;
Peterson, Phillip K. ;
Lokensgard, James R. .
JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2007, 2 (04) :297-312
[16]   Mechanisms of brain injury after intracerebral haemorrhage [J].
Xi, GH ;
Keep, RF ;
Hoff, JT .
LANCET NEUROLOGY, 2006, 5 (01) :53-63
[17]  
Inducible heat shock protein 70, interleukin-18, and tumor necrosis factor alpha correlate with outcomes in spontaneous intracerebral hemorrhage[J] . Hsin-Yuan Fang,Wen-Je Ko,Ching-Yuang Lin.Journal of Clinical Neuroscience . 2006 (5)
[18]  
Incidence and Trends of Stroke and Its Subtypes in China: Results From Three Large Cities[J] . Bin Jiang,Wen-zhi Wang,Honglei Chen,Zhen Hong,Qi-dong Yang,Sheng-ping Wu,Xiao-li Du,Qiu-ju Bao.Stroke . 2006 (1)
[19]   Matrix metalloproteinases and free radicals in cerebral ischemia [J].
Liu, KH ;
Rosenberg, GA .
FREE RADICAL BIOLOGY AND MEDICINE, 2005, 39 (01) :71-80
[20]   Metallothionein-1+2 protect the CNS after a focal brain injury [J].
Giralt, M ;
Penkowa, M ;
Lago, N ;
Molinero, A ;
Hidalgo, J .
EXPERIMENTAL NEUROLOGY, 2002, 173 (01) :114-128