百裕银杏内酯注射液抑制家兔血小板聚集作用的实验研究

被引：21

作者：

徐露 ^{[1
]}

黄彦 ^{[2
]}

机构：

[1] 重庆医科大学生化与分子药理学重点实验室

[2] 重庆市中医院

来源：

中国中医急症 | 2014年 / 23卷 / 04期

关键词：

百裕银杏内酯注射液; 血小板; 血小板活化因子; 电镜;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

1008 ;

摘要：

目的观察不同低剂量的百裕银杏内酯注射液对家兔血小板聚集功能、超微结构及PF-4和β-TG的影响。方法将日本大耳兔分为百裕银杏内酯高、中、低剂量组及生理盐水组,分别予相应药物静注1周,采用体内实验法,观察各组对血小板活化因子(PAF)诱导的家兔血小板聚集作用的影响,以及血小板超微结构和PF-4和β-TG水平的变化。结果百裕银杏内酯各剂量组较生理盐水组均能抑制PAF诱导的家兔血小板聚集,减少聚集型血小板数量并使树突型血小板突起变少变短,降低PF-4和β-TG的表达(P<0.01)。结论百裕银杏内酯注射液能够抑制PAF诱导的血小板聚集,抑制血小板的活化。

引用

页码：638 / 639+643 +643

页数：3

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