食管黏膜屏障功能及其检测方法研究进展

被引：30

作者：

刘贝妮 ^{[1
,2
]}

姚树坤 ^{[1
,2
]}

机构：

[1] 中日友好医院消化内科

[2] 中国医学科学院北京协和医学院研究生院

来源：

胃肠病学和肝病学杂志 | 2014年 / 23卷 / 12期

关键词：

食管黏膜屏障; 细胞间隙增宽; 非糜烂性反流病; 检测;

D O I：

暂无

中图分类号：

R571 [食管疾病];

学科分类号：

100201 [内科学];

摘要：

食管黏膜屏障包括上皮屏障、顶端连接复合体、化学屏障及上皮后屏障。食管黏膜屏障功能的研究对进一步明确胃食管反流病病理生理学机制具有重要意义。目前临床上对于食管黏膜屏障功能的检测尚未有效开展。本文对其功能及其检测方法的研究进展作一概述。

引用

收藏

页码：1373 / 1375

页数：3

相关论文

共 17 条

[1]

Esophageal Mucosal Integrity in Nonerosive Reflux Disease [J].

Woodland, Philip ;

Sifrim, Daniel .

JOURNAL OF CLINICAL GASTROENTEROLOGY, 2014, 48 (01) :6-12

[2]

Pathophysiology of gastro-esophageal reflux disease: a role for mucosa integrity? [J].

Farre, R. .

NEUROGASTROENTEROLOGY AND MOTILITY, 2013, 25 (10) :783-799

[3]

In vivo evaluation of acid-induced changes in oesophageal mucosa integrity and sensitivity in non-erosive reflux disease [J].

Woodland, Philip ;

Al-Zinaty, Mohannad ;

Yazaki, Etsuro ;

Sifrim, Daniel .

GUT, 2013, 62 (09) :1256-1261

[4]

The integrity of the esophageal mucosa Balance between offensive and defensive mechanisms [J].

Orlando, Roy C. .

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 2010, 24 (06) :873-882

[5]

Claudins and paracellular transport: an update [J].

Angelow, Susanne ;

Yu, Alan S. L. .

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2007, 16 (05) :459-464

[6]

Effectiveness of Proton Pump Inhibitors in Nonerosive Reflux Disease [J].

Dean, Bonnie B. ;

Gano, Anacleto D., Jr. ;

Knight, Kevin ;

Ofman, Joshua J. ;

Fass, Ronnie .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2004, 2 (08) :656-664

[7]

Dilated intercellular spaces as a marker of oesophageal damage: comparative results in gastro-oesophageal reflux disease with or without bile reflux [J].

Calabrese, C ;

Fabbri, A ;

Bortolotti, M ;

Cenacchi, G ;

Areni, A ;

Scialpi, C ;

Miglioli, M ;

Di Febo, G .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2003, 18 (05) :525-532

[8]

Desmosomal cadherins [J].

Garrod, DR ;

Merritt, AJ ;

Nie, ZX .

CURRENT OPINION IN CELL BIOLOGY, 2002, 14 (05) :537-545

[9]

Low edge damage container insert that adjusts intestinal forceps biopsies into Ussing chamber systems [J].

Stockmann, M ;

Gitter, AH ;

Sorgenfrei, D ;

Fromm, M ;

Schulzke, JD .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1999, 438 (01) :107-112

[10]

Human esophageal epithelial cells possess an Na+/H+ exchanger for H+ extrusion [J].

Tobey, NA ;

Koves, G ;

Orlando, RC .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 1998, 93 (11) :2075-2081