低谷浓度和高谷浓度万古霉素疗效与安全性比较

被引：19

作者：

蒙龙 ^{[1
]}

方芸 ^{[2
]}

丁选胜 ^{[1
]}

机构：

[1] 中国药科大学临床药学教研室

[2] 南京大学医学院附属鼓楼医院药剂科

来源：

药学与临床研究 | 2013年 / 21卷 / 01期

关键词：

万古霉素; 谷浓度; 疗效; 肾毒性;

D O I：

10.13664/j.cnki.pcr.2013.01.021

中图分类号：

R969.4 [临床疗效试验];

学科分类号：

100706 [药理学];

摘要：

目的:比较低谷浓度和高谷浓度万古霉素的疗效和安全性。方法:采用回顾性队列研究方法,回顾性收集2009～2011年135例成年患者的数据,依照平均谷浓度分为低浓度组(<15 mg.L-1)与高浓度组(≥15 mg.L-1),分别比较其临床失败率、细菌清除失败率、在院死亡率和肾毒性发生率。结果:135名患者中低浓度组与高浓度组人数分别为91例和44例。两组的临床失败率、细菌清除失败率、在院死亡率分别为37.4%vs 43.2%(校正比值比0.849)、37.4%vs 31.8%(校正比值比0.575)、7.7%vs 13.6%(校正比值比0.613),均没有显著差异,而高浓度组肾毒性发生率显著增加。结论:高谷浓度与低谷浓度万古霉素相比疗效没有显著性差异,但其肾毒性发生显著增加。

引用

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