Relationships between vancomycin minimum inhibitory concentration, dosing strategies, and outcomes in methicillin-resistant Staphylococcus aureus bacteremia

被引：28

作者：

Clemens, Evan C. ^{[1
,2
]}

Chan, Jeannie D. ^{[1
,2
]}

Lynch, John B. ^{[3
,4
]}

Dellit, Timothy H. ^{[3
,4
]}

机构：

[1] Univ Washington, Harborview Med Ctr, Dept Pharm, Seattle, WA 98104 USA

[2] Univ Washington, Sch Pharm, Seattle, WA 98104 USA

[3] Univ Washington, Harborview Med Ctr, Dept Med, Div Allergy & Infect Dis, Seattle, WA 98104 USA

[4] Univ Washington, Sch Med, Seattle, WA 98104 USA

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2011年 / 71卷 / 04期

关键词：

Methicillin-resistant Staphylococcus aureus; Bacteremia; Vancomycin; Minimum inhibitory concentration; REDUCED SUSCEPTIBILITY; DAPTOMYCIN; MORTALITY; INTERMEDIATE; FAILURE; NEPHROTOXICITY; DEFINITION; PREDICTORS; EFFICACY; THERAPY;

D O I：

10.1016/j.diagmicrobio.2011.08.002

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Retrospective study aimed to examine outcomes of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia in relationship to vancomycin minimum inhibitory concentration (VAN MIC) and serum trough concentrations among subjects who had >= 1 blood culture positive for MRSA between April 2008 and August 2009. Treatment failure occurred in 7/24 (29%) subjects with VAN MIC = 2 mg/L versus 20/94 (21%) subjects with VAN MIC <= 1.5 mg/L (adjusted OR 1.11, 95% confidence interval [CI] 0.24-5.14). Among subjects who had documented VAN serum trough concentrations, treatment failure occurred in 5/26(19%) subjects with concentrations <15 mg/L versus 18/68 (27%) subjects with concentrations >= 15 mg/L (adjusted OR 0.91, 95% CI 0.21-3.84). In conclusion, treatment outcomes were similar regardless of VAN MIC, although there was a non statistically significant trend towards decreased clinical efficacy among patients with VAN MIC = 2 mg/L. Optimization of VAN pharmacokinetic indices did not appear to correlate with clinical responses. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：408 / 414

页数：7

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