细胞凋亡与凋亡诱导因子

被引：31

作者：

张闻多 ^{[1
]}

丁文惠 ^{[2
]}

机构：

[1] 北京医院心内科

[2] 北京大学第一医院心内科

来源：

中国病理生理杂志 | 2006年 / 09期

关键词：

细胞凋亡; 凋亡诱导因子;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100103 [病原生物学];

摘要：

[A Review] The process of apoptosis is very complex.Apoptosis-inducing factor(AIF)has the ability to induce apoptosis via a caspase-independent pathway.The mature AIF protein,a flavoprotein(prosthetic group:flavine adenine dinucleotide)is normally confined to the mitochondrial intermembrane space.AIF translocates through the outer mitochondrial membrane to the cytosol and to the nucleus.AIF induces nuclear chromatin condensation,as well as large scale(V50 kb)DNA fragmentation.AIF is a phyloge-netically old,bifunctional protein with an electron acceptor/donor(oxidoreductase)function and a second apoptogenic function and AIF acts in a caspase-independent fashion.The molecular mechanisms via which AIF induces apoptosis are discussed in this review.

引用

页码：1858 / 1862

页数：5

共 4 条

[1]

A novel p53-inducible apoptogenic gene; PRG3; encodes a homologue of the apoptosis-inducing factor (AIF).[J].Yoichi Ohiro;Igor Garkavtsev;Shinichiro Kobayashi;Kodangattil R. Sreekumar;Regan Nantz;Bryan T. Higashikubo;Shannon L. Duffy;Ryuji Higashikubo;Anny Usheva;David Gius;Nikolai Kley;Nobuo Horikoshi.FEBS Letters.2002, 1

[2]

Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria.[J].Céline Candé;Isabelle Cohen;Eric Daugas;Luigi Ravagnan;Nathanael Larochette;Naoufal Zamzami;Guido Kroemer.Biochimie.2002, 2

[3]

Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c [J].