自愿适量运动对脑的有益作用及其生物学机制(英文)

被引：14

作者：

马强

机构：

[1] 军事医学科学院卫生学环境医学研究所

来源：

NeuroscienceBulletin | 2008年 / 04期

关键词：

运动; 脑; 认知; 去甲肾上腺素; 5-羟色胺; 脑源性神经营养因子;

D O I：

暂无

中图分类号：

R741 [神经病学];

学科分类号：

摘要：

本文综述了在人和动物方面有关自愿适量运动有益于脑作用的研究,包括改善心理状态和认知功能、增强心理幸福感、降低老年痴呆症发生危险度和发挥抗抑郁及抗焦虑药的作用等。运动对脑的作用机制包含上游和下游两方面:上游途径主要涉及投射到海马的几种神经递质系统的功能增强,其中包括去甲肾上腺素、5-羟色胺、乙酰胆碱和γ-氨基丁酸;下游途径主要涉及脑源性神经营养因子的表达提高和神经元发生的增强;其中,激活β受体介导的去甲肾上腺素能神经的传递被认为是运动导致脑源性神经营养因子表达增强的前提,上述过程在细胞内的可能信号转导机制主要涉及G-蛋白偶联受体-促分裂原活化蛋白激酶-磷脂酰肌醇(-3)激酶等细胞信号转导通路的交互及正反馈调控。

引用

页码：265 / 270

页数：6

共 10 条

[1] Changes of 5-hydroxytryptamine and tryptophan hydroxylase expression in the ventral horn of spinal cord
Xu C.-X.
Liu H.-T.
Wang J.
[J]. Neuroscience Bulletin, 2008, 24 (1) : 29 - 33
[2] A neurotrophic model for stress-related mood disorders
Duman, Ronald S.
Monteggia, Lisa M.
[J]. BIOLOGICAL PSYCHIATRY, 2006, 59 (12) : 1116 - 1127
[3] Neurotrophic factors and regulation of mood: Role of exercise, diet and metabolism[J] . Ronald S. Duman.Neurobiology of Aging . 2005 (1)
[4] Effect of neurokinin-1 receptor antagonists on serotoninergic, noradrenergic and hippocampal neurons: Comparison with antidepressant drugs[J] . Gabriella Gobbi,Pierre Blier.Peptides . 2005 (8)
[5] Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male sprague–dawley rats in vivo[J] . J Farmer,X Zhao,H van Praag,K Wodtke,F.H Gage,B.R Christie.Neuroscience . 2004 (1)
[6] BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders[J] . Mark P. Mattson,Stuart Maudsley,Bronwen Martin.Trends in Neurosciences . 2004 (10)
[7] Noradrenergic and serotonergic blockade inhibits BDNF mRNA activation following exercise and antidepressant
Ivy, AS
Rodriguez, FG
Garcia, C
Chen, MJ
Russo-Neustadt, AA
[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2003, 75 (01) : 81 - 88
[8] Exercise: a behavioral intervention to enhance brain health and plasticity[J] . Carl W. Cotman,Nicole C. Berchtold.Trends in Neurosciences . 2002 (6)
[9] Physical Exercise and Psychological Well-Being: A Population Study in Finland[J] . Peter Hassmén,Nathalie Koivula,Antti Uutela.Preventive Medicine . 2000 (1)
[10] Exercise-induced regulation of brain-derived neurotrophic factor （BDNF） transcripts in the rat hippocampus[J] . Heather S. Oliff,Nicole C. Berchtold,Paul Isackson,Carl W. Cotman.Molecular Brain Research . 1998 (1)

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