人乳头瘤病毒疫苗临床免疫原性评价方法研究进展

被引：3

作者：

聂建辉

王佑春

黄维金

机构：

[1] 中国食品药品检定研究院艾滋病性病病毒疫苗室

来源：

中华微生物学和免疫学杂志 | 2018年 / 08期

关键词：

人乳头瘤病毒; 临床试验; 免疫原性; 中和抗体;

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

人乳头瘤病毒(human papillomavims, HPV)感染是最常见的经性传播的病毒感染,该病毒的持续感染可以引起宫颈、肛门等部位的癌症,目前已有3种上市疫苗可以预防HPV感染及由其导致的疾病。HPV疫苗诱导的中和抗体是其发挥保护作用的基础,HPV疫苗临床免疫原性评价至关重要,为疫苗免疫持久性研究、小年龄组免疫桥接、不同免疫程序比较等方面提供了数据支持。但目前尚无统一的临床免疫原性评价方法,不同疫苗临床试验免疫原性数据可比性较差,亟待建立与疫苗保护相关性较高的高通量免疫原性评价方法,并建立相应的标准物质,在不同实验室完成方法转移和验证,实现检测结果的可比性,推动HPV预防性疫苗的研发和评价工作。

引用

页码：629 / 634

页数：6

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