哺乳动物昼夜节律机制研究进展

被引：36

作者：

安扬

徐璎

机构：

[1] 南京大学模式动物研究所

来源：

生命科学 | 2015年 / 27卷 / 11期

关键词：

昼夜节律; 哺乳动物; 分子机制; 输入系统; 输出系统; 代谢;

D O I：

10.13376/j.cbls/2015190

中图分类号：

Q418 [生长、发育与生殖];

学科分类号：

071003 [生理学];

摘要：

地球以24 h为自转周期,为此,生活在地球上的不同生物也通过自身约24 h的内在节律的形成来适应昼夜环境的变化,这一系统即为生物钟。在哺乳类动物中,生物钟主要通过涵盖转录与翻译水平的核心连锁环驱动特异性的转录因子来维持整个基因组转录的昼夜节律性,从而使得不同组织与器官的生理功能能够适应环境剧烈的昼夜变化。现将在综述哺乳类动物昼夜节律形成机制及其生理功能研究进展的基础上,对今后的研究方向作出展望。

引用

页码：1372 / 1379

页数：8

共 64 条

[1]

Redox rhythm reinforces the circadian clock to gate immune response [J].

Zhou, Mian ;

Wang, Wei ;

Karapetyan, Sargis ;

Mwimba, Musoki ;

Marques, Jorge ;

Buchler, Nicolas E. ;

Dong, Xinnian .

NATURE, 2015, 523 (7561) :472-U221

[2]

Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus [J].

Xu, Haiyan ;

Gustafson, Chelsea L. ;

Sammons, Patrick J. ;

Khan, Sanjoy K. ;

Parsley, Nicole C. ;

Ramanathan, Chidambaram ;

Lee, Hsiau-Wei ;

Liu, Andrew C. ;

Partch, Carrie L. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2015, 22 (06) :476-U70

[3]

The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation [J].

Lipton, Jonathan O. ;

Yuan, Elizabeth D. ;

Boyle, Lara M. ;

Ebrahimi-Fakhari, Darius ;

Kwiatkowski, Erica ;

Nathan, Ashwin ;

Guettler, Thomas ;

Davis, Fred ;

Asara, John M. ;

Sahin, Mustafa .

CELL, 2015, 161 (05) :1138-1151

[4]

Optimal Implementations for Reliable Circadian Clocks [J].

Hasegawa, Yoshihiko ;

Arita, Masanori .

PHYSICAL REVIEW LETTERS, 2014, 113 (10)

[5]

An intensity ratio of interlocking loops determines circadian period length [J].

Yan, Jie ;

Shi, Guangsen ;

Zhang, Zhihui ;

Wu, Xi ;

Liu, Zhiwei ;

Xing, Lijuan ;

Qu, Zhipeng ;

Dong, Zhen ;

Yang, Ling ;

Xu, Ying .

NUCLEIC ACIDS RESEARCH, 2014, 42 (16) :10278-10287

[6]

Molecular Assembly of the Period-Cryptochrome Circadian Transcriptional Repressor Complex [J].

Nangle, Shannon N. ;

Rosensweig, Clark ;

Koike, Nobuya ;

Tei, Hajime ;

Takahashi, Joseph S. ;

Green, Carla B. ;

Zheng, Ning .

ELIFE, 2014, 3 :1-14

[7]

Interaction of Circadian Clock Proteins CRY1 and PER2 Is Modulated by Zinc Binding and Disulfide Bond Formation [J].

Schmalen, Ira ;

Reischl, Silke ;

Wallach, Thomas ;

Klemz, Roman ;

Grudziecki, Astrid ;

Prabu, J. Rajan ;

Benda, Christian ;

Kramer, Achim ;

Wolf, Eva .

CELL, 2014, 157 (05) :1203-1215

[8]

A Positive Role for PERIOD in Mammalian Circadian Gene Expression [J].

Akashi, Makoto ;

Okamoto, Akihiko ;

Tsuchiya, Yoshiki ;

Todo, Takeshi ;

Nishida, Eisuke ;

Node, Koichi .

CELL REPORTS, 2014, 7 (04) :1056-1064

[9]

PER1 Phosphorylation Specifies Feeding Rhythm in Mice.[J].Zhiwei Liu;Moli Huang;Xi Wu;Guangsen Shi;Lijuan Xing;Zhen Dong;Zhipeng Qu;Jie Yan;Ling Yang;Satchidananda Panda;Ying Xu.Cell Reports.2014,

[10]

Circadian control of glucose metabolism [J].

Kalsbeek, Andries ;

la Fleur, Susanne ;

Fliers, Eric .

MOLECULAR METABOLISM, 2014, 3 (04) :372-383

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