骨吸收与骨形成耦联中Eph/ephrin信号转导的研究进展

被引：7

作者：

赵鹃

毛英杰

谷志远

机构：

[1] 浙江大学医学院附属口腔医院

来源：

生物化学与生物物理进展 | 2009年 / 36卷 / 09期

关键词：

破骨细胞; 成骨细胞; Eph; ephrin; 双向信号转导;

D O I：

暂无

中图分类号：

R68 [骨科学（运动系疾病、矫形外科学）];

学科分类号：

100220 [骨科学];

摘要：

破骨细胞的骨吸收活动与成骨细胞的骨形成活动相互作用调节,形成一种特殊的耦联机制,影响骨骼生长、发育及正常骨组织结构的维持.最近几年提出的Eph/ephrin双向信号转导在骨吸收与骨形成耦联中的研究越来越受到关注.从Eph/ephrin分子结构、信号转导机制及生物学意义等几方面对该理论作一阐述.

引用

页码：1101 / 1105

页数：5

共 13 条

[1]

Eph-ephrin介导反向信号传递的研究进展附视频 [J].

王琳 ;

郑国光 .

生物化学与生物物理进展, 2007, (11) :1142-1146

[2]

Eph-ephrin bidirectional signaling in physiology and disease [J].

Pasquale, Elena B. .

CELL, 2008, 133 (01) :38-52

[3]

Distribution, gene expression, and functional role of EphA4 during ossification [J].

Kuroda, Chisa ;

Kubota, Satoshi ;

Kawata, Kazumi ;

Aoyama, Eriko ;

Sumiyoshi, Kumi ;

Oka, Morihiko ;

Inoue, Miho ;

Minagi, Shogo ;

Takigawa, Masaharu .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 374 (01) :22-27

[4]

Osteoclast–osteoblast communication.[J].Koichi Matsuo;Naoko Irie.Archives of Biochemistry and Biophysics.2008, 2

[5]

Bidirectional Eph–ephrin signaling during axon guidance.[J].Joaquim Egea;Rüdiger Klein.Trends in Cell Biology.2007, 5

[6]

Estrogen prevents bone loss via estrogen receptor α and induction of Fas ligand in osteoclasts [J].

Nakamura, Takashi ;

Imai, Yuuki ;

Matsumoto, Takahiro ;

Sato, Shingo ;

Takeuchi, Kazusane ;

Igarashi, Katsuhide ;

Harada, Yoshifumi ;

Azuma, Yoshiaki ;

Krust, Andree ;

Yamamoto, Yoko ;

Nishina, Hiroshi ;

Takeda, Shu ;

Takayanagi, Hiroshi ;

Metzger, Daniel ;

Kanno, Jun ;

Takaoka, Kunio ;

Martin, T. John ;

Chambon, Pierre ;

Kato, Shigeaki .

CELL, 2007, 130 (05) :811-823

[7]

Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies craniofrontonasal syndrome [J].

Davy, Alice ;

Bush, Jeffrey O. ;

Soriano, Philippe .

PLOS BIOLOGY, 2006, 4 (10) :1763-1776

[8]

Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis [J].

Zhao, Chen ;

Irie, Naoko ;

Takada, Yasunari ;

Shimoda, Kouji ;

Miyamoto, Takeshi ;

Nishiwaki, Toru ;

Suda, Toshio ;

Matsuo, Koichi .

CELL METABOLISM, 2006, 4 (02) :111-121

[9]

Boning up on ephrin signaling [J].

Mundy, Gregory R. ;

Elefteriou, Florent .

CELL, 2006, 126 (03) :441-443

[10]

Eph receptor signalling; dimerisation just isn't enough [J].

Vearing, CJ ;

Lackmann, M .

GROWTH FACTORS, 2005, 23 (01) :67-76

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