复方丹参滴丸抑制高脂喂养犬血小板过度活化

被引：5

作者：

张雷

刘彩玲

靳婷婷

机构：

[1] 天津解放军第医院干部病房一科

来源：

中国中医基础医学杂志 | 2007年 / 12期

关键词：

胰岛素抵抗; 血小板活化标志; 抗氧化; 动物模型;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

1008 ;

摘要：

目的:试图研究复方丹参滴丸对高脂喂养造成的胰岛素抵抗狗模型血小板功能影响。方法:选24只比格犬,18只犬经高脂喂养6个月复制胰岛素抵抗模型,随后,其中6只给予阿司匹林(250mg/d),6只给予复方丹参滴丸(1000mg/d),继续喂养4个月。结果:高脂喂养6个月后,动物出现明显的代谢异常和胰岛素抵抗,同时出现血小板过度活化的表现复方丹参滴丸可显著降低血浆胆固醇水平,并表现出明显的抗氧化作用。阿司匹林和复方丹参滴丸都能抑制血小板的过度活化。与阿司匹林相比,复方丹参滴丸对血小板最大聚集率及血小板表面黏附分子表达的抑制作用更显著。结论:复方丹参滴丸能有效抑制胰岛素抵抗犬血小板过度活化。

引用

页码：904 / 907

页数：4

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