非白念珠菌对常用抗真菌药物的敏感性分析

被引：8

作者：

沈银忠 ^{[1
]}

卢洪洲 ^{[1
,2
]}

张永信 ^{[2
]}

机构：

[1] 上海市公共卫生临床中心

[2] 复旦大学附属华山医院

来源：

中国抗生素杂志 | 2010年 / 35卷 / 01期

关键词：

非白念珠菌; 药敏; 纸片扩散法;

D O I：

10.13461/j.cnki.cja.004508

中图分类号：

R519 [真菌与放线菌传染病];

学科分类号：

摘要：

目的了解非白念珠菌对我国常用抗真菌药物的耐药状况。方法采用Rosco Neo-Sensitab纸片扩散法检测116株非念珠菌对常用抗真菌药物的敏感性。结果除2株光滑念珠菌对两性霉素B耐药外,其它菌株均对两性霉素B敏感;86.4%的热带念珠菌和80%的近平滑念珠菌对氟康唑敏感;光滑念珠菌对两性霉素B、氟康唑和伊曲康唑的耐药率分别为3.6%、16.1%和10.7%;所有克柔念珠菌对氟康唑和氟胞嘧啶均耐药。结论绝大多数非白念珠菌对两性霉素B敏感,克柔念珠菌对氟胞嘧啶及三唑类抗真菌药物的耐药率高,光滑念珠菌对常用抗真菌药物包括两性霉素B的敏感性低,对三唑类抗真菌药物的耐药率高,且对三唑类抗真菌药物存在交叉耐药。

引用

页码：72 / 76

页数：5

共 7 条

[1] Fungemia at a tertiary care hospital: incidence, therapy, and distribution and antifungal susceptibility of causative species[J] . K. Lagrou,J. Verhaegen,W. E. Peetermans,T. Rijdt,J. Maertens,E. Wijngaerden.European Journal of Clinical Microbiology ＆ Infectious Diseases . 2007 (8)
[2] Susceptibilities to amphotericin B and fluconazole of Candida species in TSARY 2002
Yang, YL
Li, SY
Cheng, HH
Lo, HJ
[J]. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2005, 51 (03) : 179 - 183
[3] Candida species distribution in bloodstream cultures in Lyon, France, 1998–2001[J] . D. Martin,F. Persat,M.-A. Piens,S. Picot.European Journal of Clinical Microbiology ＆ Infectious Diseases . 2005 (5)
[4] In vitro fluconazole susceptibility of 1565 clinical isolates of Candida species evaluated by the disk diffusion method performed using NCCLS M44-A guidelines
Testore, GP
Dori, L
Buonomini, AR
Schito, GC
Soro, O
Fortina, G
Andreoni, S
Carlone, N
Tullio, V
Andreoni, M
[J]. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2004, 50 (03) : 187 - 192
[5] Trends in frequency and susceptibilities of Candida glabrata bloodstream isolates at a University Hospital
Braddley, JW
Smith, AM
Moser, SA
Pappas, PG
[J]. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2001, 39 (03) : 199 - 201
[6] Clinical applicability of antifungal susceptibility testing on non-Candida albicans species in hospitalized patients
Wong-Beringer, A
Hindler, J
Brankovic, L
Muehlbauer, L
Steele-Moore, L
[J]. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2001, 39 (01) : 25 - 31
[7] In Vitro susceptibility of 137 Candida sp. Isolates from HIV positive patients to several antifungal drugs[J] . S. Magaldi,S. Mata,C. Hartung,G. Verde,L. Deibis,Y. Roldín,C. Marcano.Mycopathologia . 2001 (2)

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