Exosome DNA: An untold story of cancer

被引：24

作者：

Bhattacharya, Bikramjit ^{[1
]}

Dhar, Rajib ^{[2
]}

Mukherjee, Sayantanee ^{[3
]}

Gorai, Sukhamoy ^{[4
]}

Devi, Arikketh ^{[2
,10
]}

Krishnan, Anand ^{[5
]}

Alexiou, Athanasios ^{[6
,7
]}

Papadakis, Marios ^{[8
,9
]}

机构：

[1] Vellore Inst Technol VIT, Sch Biosci & Technol, Dept Appl Microbiol, Vellore, India

[2] SRM Inst Sci & Technol, Dept Genet Engn, Canc & Stem Cell Biol Lab, Kattankulathur, India

[3] Amrita Inst Med Sci, Amrita Sch Nano Sci & Mol Med, Kochi, India

[4] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL USA

[5] Univ Free State, Fac Hlth Sci, Sch Pathol, Dept Chem Pathol, Bloemfontein, South Africa

[6] Novel Global Community Educ Fdn, Dept Sci & Engn, Hebersham, NSW, Australia

[7] AFNP Med, Vienna, Austria

[8] Univ Hosp Witten Herdecke, Dept Surg 2, Wuppertal, Germany

[9] Univ Hosp Witten Herdecke, Dept Surg 2, Heusnerstr 40, D-42283 Wuppertal, Germany

[10] SRM Inst Sci & Technol, Dept Genet Engn, Canc & Stem Cell Biol Lab, Kattankulathur 603203, Tamil Nadu, India

来源：

CLINICAL AND TRANSLATIONAL DISCOVERY | 2023年 / 3卷 / 04期

关键词：

biomarker; epigenetic regulation; exosome-DNA; exosomes; metastasis; IDENTIFICATION; KRAS;

D O I：

10.1002/ctd2.218

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Exosome is nanosized tiny membrane-bound vesicles and is a subpopulation of extracellular vesicles (EVs). In general, it participates in intercellular communication and acts as a messenger of several pathological complications. Exosome and cancer interlink is the most exciting domain of current cancer research. The internal molecular cargos (proteins, lipids, metabolites, miRNA, and DNA) of tumor derived exosomes (TEXs) are capable of transforming normal cells into tumor phenotypes. Exosome DNA is the less explored area of EVs research. It is involved in several events in cancer progression such as uncontrol cell growth, reprogramming of immune cells, metastasis, and therapeutic resistance. Exo-DNA is also involved in epigenetic alteration, which promotes cancer. It has a great impact on cancer theranostics (biomarker and therapeutics) research. Exo-DNA-based cancer examination supports more detailed cancer research.

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