Naringin@Metal-Organic Framework as a Multifunctional Bioplatform

被引：15

作者：

Ge, Xueying ^{[1
]}

Jiang, Fangchao ^{[2
,4
]}

Wang, Minghui

Chen, Meng ^{[3
]}

Li, Yiming ^{[3
]}

Phipps, Joshua ^{[1
]}

Cai, Jianfeng ^{[3
]}

Xie, Jin ^{[2
]}

Ong, Jane ^{[4
]}

Dubovoy, Viktor ^{[4
]}

Masters, James G. ^{[4
]}

Pan, Long ^{[4
]}

Ma, Shengqian ^{[1
]}

机构：

[1] Univ North Texas, Dept Chem, Denton, TX 76201 USA

[2] Univ Georgia, Dept Chem, Athens, GA 30602 USA

[3] Univ S Florida, Dept Chem, Tampa, FL 33620 USA

[4] Colgate Palmol Co, Piscataway, NJ 08855 USA

来源：

ACS APPLIED MATERIALS & INTERFACES | 2023年 / 15卷 / 01期

关键词：

cancer; Gram-positive bacteria; immune function; metal-organic framework; naringin; DRUG-DELIVERY; NATURAL-PRODUCTS; NANOPARTICLES; PLATFORM; RELEASE;

D O I：

10.1021/acsami.2c19904

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

Naringin, a natural product, can be used as a therapeutic agent due to its low systemic toxicity and negligible adverse effect. However, due to its hydrophobic nature and thereby low solubility, high-dose treatment is required when used for human therapy. Herein, we demonstrate the employment of a metal-organic framework (MOF) as a nontoxic loading carrier to encapsulate naringin, and the afforded nairngin@MOF composite can serve as a multifunctional bioplatform capable of treating Gram-positive bacteria and certain cancers by slowly and progressively releasing the encapsulated naringin as well as improving and modulating immune system functions through synergy between naringin and the MOF.

引用

页码：677 / 683

页数：7

共 35 条

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Antibacterial Activity of Some Flavonoids and Organic Acids Widely Distributed in Plants [J].